Insulin-like growth factor II IRES
Encyclopedia
The insulin-like growth factor II (IGF-II) internal ribosome entry site IRES is found in the 5' UTR of IGF-II
leader 2 mRNA. This RNA element
allows cap-independent translation
of the mRNA and it is thought that this family may facilitate a continuous IGF-II production in rapidly dividing cells during development.
Insulin-like growth factor 2
Insulin-like growth factor 2 is one of three protein hormones that share structural similarity to insulin.-Gene structure:In humans, the IGF2 gene is located on chromosome 11p15.5, a region which contains numerous imprinted genes. In mice this homologous region is found at distal chromosome 7...
leader 2 mRNA. This RNA element
Cis-regulatory element
A cis-regulatory element or cis-element is a region of DNA or RNA that regulates the expression of genes located on that same molecule of DNA . This term is constructed from the Latin word cis, which means "on the same side as". These cis-regulatory elements are often binding sites for one or...
allows cap-independent translation
Translation
Translation is the communication of the meaning of a source-language text by means of an equivalent target-language text. Whereas interpreting undoubtedly antedates writing, translation began only after the appearance of written literature; there exist partial translations of the Sumerian Epic of...
of the mRNA and it is thought that this family may facilitate a continuous IGF-II production in rapidly dividing cells during development.