Iminodiacetic acid
Encyclopedia
Iminodiacetic acid, HN2, often abbreviated to IDA, is an dicarboxylic acid amine. The iminodiacetate anion can act as a tridentate ligand
to form a metal complex with two, fused, five membered chelate rings. The proton on the nitrogen atom can be replaced by a carbon atom of a polymer to create an ion-exchange resin, such as chelex 100
.
IDA forms stronger complexes than the bidentate ligand glycine
and weaker complexes than the tetradentate ligand nitrilotriacetic acid
.
By capillary electrophoresis
IDA is typically used for modulating peptide mobility
.
Ligand
In coordination chemistry, a ligand is an ion or molecule that binds to a central metal atom to form a coordination complex. The bonding between metal and ligand generally involves formal donation of one or more of the ligand's electron pairs. The nature of metal-ligand bonding can range from...
to form a metal complex with two, fused, five membered chelate rings. The proton on the nitrogen atom can be replaced by a carbon atom of a polymer to create an ion-exchange resin, such as chelex 100
Chelex 100
Chelex 100 is a chelating material from Bio-Rad used to purify other compounds via ion exchange. It is noteworthy for its ability to bind transition metal ions.It is a styrene-divinylbenzene co-polymer containing iminodiacetic acid groups....
.
IDA forms stronger complexes than the bidentate ligand glycine
Glycine
Glycine is an organic compound with the formula NH2CH2COOH. Having a hydrogen substituent as its 'side chain', glycine is the smallest of the 20 amino acids commonly found in proteins. Its codons are GGU, GGC, GGA, GGG cf. the genetic code.Glycine is a colourless, sweet-tasting crystalline solid...
and weaker complexes than the tetradentate ligand nitrilotriacetic acid
Nitrilotriacetic acid
Nitrilotriacetic acid , C6H9NO6, is a polyamino carboxylic acid and is used as a chelating agent which forms coordination compounds with metal ions such as Ca2+, Cu2+ or Fe3+.The uses of NTA are similar to that of EDTA...
.
By capillary electrophoresis
Capillary electrophoresis
Capillary electrophoresis , also known as capillary zone electrophoresis , can be used to separate ionic species by their charge and frictional forces and hydrodynamic radius. In traditional electrophoresis, electrically charged analytes move in a conductive liquid medium under the influence of an...
IDA is typically used for modulating peptide mobility
Electrical mobility
Electrical mobility is the ability of charged particles to move through a medium in response to an electric field that is pulling them...
.