HDAC3
Encyclopedia
Histone deacetylase 3 is an enzyme
that in humans is encoded by the HDAC3 gene
.
with HDAC9
, HDAC7A
, Retinoblastoma protein
, RBBP4
, Testicular receptor 2
, MAP3K7IP2
, Peroxisome proliferator-activated receptor delta
, GTF2I
, Histone deacetylase 5
, RELA
, MAPK11
, TBL1X
, Nuclear receptor co-repressor 1
, Cyclin D1
, Nuclear receptor co-repressor 2
, ZBTB33
, SUV39H1
, Peroxisome proliferator-activated receptor gamma
, T-complex 1
, HDAC4
, CBFA2T3
, GPS2
, YY1
, RUNX2
, GATA1
, GATA2
, Promyelocytic leukemia protein
and Ubiquitin C
.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the HDAC3 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Interactions
HDAC3 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with HDAC9
HDAC9
Histone deacetylase 9 is an enzyme that in humans is encoded by the HDAC9 gene.-Interactions:HDAC9 has been shown to interact with SIN3A, Nuclear receptor co-repressor 1, CBX5, HDAC3, Myocyte-specific enhancer factor 2A and SUV39H1....
, HDAC7A
HDAC7A
Histone deacetylase 7 is an enzyme that in humans is encoded by the HDAC7 gene.-Interactions:HDAC7A has been shown to interact with Endothelin receptor type A, HDAC3, HTATIP, BCL6, Nuclear receptor co-repressor 1 and IKZF1.-Further reading:...
, Retinoblastoma protein
Retinoblastoma protein
The retinoblastoma protein is a tumor suppressor protein that is dysfunctional in the majority types of cancer. One highly studied function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide...
, RBBP4
RBBP4
Histone-binding protein RBBP4 is a protein that in humans is encoded by the RBBP4 gene.-Interactions:RBBP4 has been shown to interact with HDAC1, Histone deacetylase 2, SIN3A, Retinoblastoma protein, SAP30, CREB-binding protein, GATAD2B, BRCA1, MTA2 and HDAC3.-Further reading:...
, Testicular receptor 2
Testicular receptor 2
The testicular receptor 2 also known as NR2C1 is protein that in humans is encoded by the NR2C1 gene...
, MAP3K7IP2
MAP3K7IP2
Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 is an enzyme that in humans is encoded by the MAP3K7IP2 gene.The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK...
, Peroxisome proliferator-activated receptor delta
Peroxisome proliferator-activated receptor delta
Peroxisome proliferator-activated receptor beta or delta , also known as NR1C2 is a nuclear receptor that in humans is encoded by the PPARD gene....
, GTF2I
GTF2I
General transcription factor II-I is a protein that in humans is encoded by the GTF2I gene.-Interactions:GTF2I has been shown to interact with USF1 , Histone deacetylase 2, PRKG1, Myc, MAPK3, HDAC3, Serum response factor and Bruton's tyrosine kinase.-Further reading:...
, Histone deacetylase 5
Histone deacetylase 5
Histone deacetylase 5 is an enzyme that in humans is encoded by the HDAC5 gene.-Interactions:Histone deacetylase 5 has been shown to interact with Zinc finger and BTB domain-containing protein 16, BCL6, CBX5, YWHAQ, Myocyte-specific enhancer factor 2A, Nuclear receptor co-repressor 1, IKZF1,...
, RELA
RELA
Transcription factor p65 is a protein that in humans is encoded by the RELA gene.-Interactions:RELA has been shown to interact with NFKBIB, ETHE1, NFKBIE, RFC1, TRIB3, CREB binding protein, Neutrophil cytosolic factor 1, Glucocorticoid receptor, MTPN, BRCA1, C-Fos, POU2F1, BTRC, TATA-binding...
, MAPK11
MAPK11
Mitogen-activated protein kinase 11 is an enzyme that in humans is encoded by the MAPK11 gene.-Interactions:MAPK11 has been shown to interact with HDAC3 and Promyelocytic leukemia protein.-Further reading:...
, TBL1X
TBL1X
Transducin -like 1X-linked, also known as TBL1X, is a protein which in humans is encoded by the TBL1X gene.- Function :The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to...
, Nuclear receptor co-repressor 1
Nuclear receptor co-repressor 1
The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 is a protein that in humans is encoded by the NCOR1 gene....
, Cyclin D1
Cyclin D1
G1/S-specific cyclin-D1 is a protein that in humans is encoded by the CCND1 gene.Immunohistochemical staining of cyclin D1 antibodies is used to diagnose mantle cell lymphoma.-Interactions:...
, Nuclear receptor co-repressor 2
Nuclear receptor co-repressor 2
The nuclear receptor co-repressor 2 is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR2 assists nuclear receptors in the down regulation of target...
, ZBTB33
ZBTB33
Transcriptional regulator Kaiso is a protein that in humans is encoded by the ZBTB33 gene.-Interactions:ZBTB33 has been shown to interact with HDAC3, Nuclear receptor co-repressor 1 and CTNND1....
, SUV39H1
SUV39H1
Histone-lysine N-methyltransferase SUV39H1 is an enzyme that in humans is encoded by the SUV39H1 gene.-Interactions:SUV39H1 has been shown to interact with HDAC9, HDAC1, Histone deacetylase 2, Retinoblastoma protein, CBX5, HDAC3, DNMT3A, MBD1, RUNX1, SBF1 and CBX1.-Further reading:...
, Peroxisome proliferator-activated receptor gamma
Peroxisome proliferator-activated receptor gamma
Peroxisome proliferator-activated receptor gamma , also known as the glitazone receptor, or NR1C3 is a type II nuclear receptor that in humans is encoded by the PPARG gene.Two isoforms of PPARG are detected in the human and in the mouse: PPAR-γ1 and...
, T-complex 1
T-complex 1
T-complex protein 1 subunit alpha is a protein that in humans is encoded by the TCP1 gene.-Interactions:T-complex 1 has been shown to interact with PPP4C and HDAC3.-Further reading:...
, HDAC4
HDAC4
Histone deacetylase 4, also known as HDAC4, is a protein which in humans is encoded by the HDAC4 gene.- Function :Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects...
, CBFA2T3
CBFA2T3
Protein CBFA2T3 is a protein that in humans is encoded by the CBFA2T3 gene.-Interactions:CBFA2T3 has been shown to interact with HDAC1, HDAC3, TCF3, LDB1, TAL1, RUNX1T1 and PRKAR2A.-Further reading:...
, GPS2
GPS2 (gene)
G protein pathway suppressor 2 is a protein that in humans is encoded by the GPS2 gene.-Interactions:GPS2 has been shown to interact with Cyclin A1, TBL1X, Nuclear receptor co-repressor 1, P53, EP300, HDAC3 and C21orf7.-Further reading:...
, YY1
YY1
Transcriptional repressor protein YY1 is a protein that in humans is encoded by the YY1 gene.-Interactions:YY1 has been shown to interact with Histone deacetylase 2, FKBP3, ATF6, Myc, SAP30, EP300, HDAC3, NOTCH1 and RYBP....
, RUNX2
Runx2
Runt-related transcription factor 2 also known as core-binding factor subunit alpha-1 is a protein that in humans is encoded by the RUNX2 gene RUNX2 is a key transcription factor associated with osteoblast differentiation....
, GATA1
GATA1
Erythroid transcription factor also known as GATA-binding factor 1 or GATA-1 is a protein that in humans is encoded by the GATA1 gene....
, GATA2
GATA2
GATA binding protein 2, also known as GATA2, is a human gene. The protein encoded by this gene is a transcription factor.The GATA family of transcription factors, which contain zinc fingers in their DNA binding domain, have emerged as candidate regulators of gene expression in hematopoietic cells...
, Promyelocytic leukemia protein
Promyelocytic leukemia protein
Probable transcription factor PML is a tumor suppressor protein that in humans is encoded by the PML gene.-Interactions:Promyelocytic leukemia protein has been shown to interact with Retinoic acid receptor alpha, HDAC1, Nerve Growth factor IB, SKI protein, Zinc finger and BTB domain-containing...
and Ubiquitin C
Ubiquitin C
Ubiquitin is a protein that in humans is encoded by the UBC gene.-Interactions:Ubiquitin C has been shown to interact with SCNN1A, SCNN1G, Parkin , P70-S6 Kinase 1, TRAF6, HDAC3, SFPQ, S100A10, Mothers against decapentaplegic homolog 3, NOTCH1, HIF1A, Epidermal growth factor receptor, E2F1,...
.