GRHPR
Encyclopedia
Glyoxylate reductase/hydroxypyruvate reductase is an enzyme
that in humans is encoded by the GRHPR gene
.
This gene encodes an enzyme
with hydroxypyruvate reductase
, glyoxylate reductase
, and D-glycerate dehydrogenase
enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria
is caused by mutations in this gene. GRHPR mutation analysis needs to pay attention to primer design, because allele dropout can cause false-positive result.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the GRHPR gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
This gene encodes an enzyme
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
with hydroxypyruvate reductase
Hydroxypyruvate reductase
In enzymology, a hydroxypyruvate reductase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are D-glycerate, NAD+, and NADP+, whereas its 4 products are hydroxypyruvate, NADH, NADPH, and H+....
, glyoxylate reductase
Glyoxylate reductase
In enzymology, a glyoxylate reductase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are glycolate and NAD+, whereas its 3 products are glyoxylate, NADH, and H+....
, and D-glycerate dehydrogenase
Glycerate dehydrogenase
In enzymology, a glycerate dehydrogenase is an enzyme that catalyzes the chemical reaction-glycerate + NAD+ \rightleftharpoons hydroxypyruvate + NADH + H+...
enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria
Hyperoxaluria
Hyperoxaluria is an excessive urinary excretion of oxalate. Individuals with hyperoxaluria often have calcium oxalate kidney stones. Sometimes called Bird's disease, after Golding Bird who was first to describe the condition.-Causes:...
is caused by mutations in this gene. GRHPR mutation analysis needs to pay attention to primer design, because allele dropout can cause false-positive result.