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Ferrochelatase is an enzyme that catalyses the terminal (eighth) step in the biosynthesis of
hemeA heme or haem is a prosthetic group that consists of an iron atom contained in the center of a large heterocyclic organic ring called a porphyrin. Not all porphyrins contain iron, but a substantial fraction of porphyrin-containing metalloproteins have heme as their prosthetic group; these are...
, converting
protoporphyrin IXProtoporphyrin IX, in the metabolism of porphyrin, is created by the enzyme protoporphyrinogen oxidase.-Heme b biosynthesis:In heme biosynthesis, the enzyme ferrochelatase converts it into heme b Protoporphyrin IX, in the metabolism of porphyrin, is created by the enzyme protoporphyrinogen...
into
hemeA heme or haem is a prosthetic group that consists of an iron atom contained in the center of a large heterocyclic organic ring called a porphyrin. Not all porphyrins contain iron, but a substantial fraction of porphyrin-containing metalloproteins have heme as their prosthetic group; these are...
. It catalyses the reaction:
- protoporphyrin + Fe++ ↔ protoheme + 2 H+.
A ferrochelatase enzyme consists of 497 amino acid residues with a m.w. of 55.4 kDa.
Interactions
Ferrochelatase has been shown to
interactProtein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with
ABCB7ATP-binding cassette sub-family B member 7, mitochondrial is a protein that in humans is encoded by the ABCB7 gene.-Interactions:ABCB7 has been shown to interact with Ferrochelatase.- External Links :*...
.
Further reading
External links