Equine herpesvirus 4
Encyclopedia
Equine herpesvirus 4 is a virus
of the family Herpesviridae
that cause rhinopneumonitis in horse
s. It is the most important viral cause of respiratory infection in foals. Like other herpes viruses, EHV-4 causes a lifelong latent infection in affected animals. These horses are usually the source for new infection for foals over two months old, weanlings, and yearlings. Symptoms include fever, loss of appetite, and discharge from the nose. Most infected animals recover in one to three weeks, but death can occur in environments with overcrowding and other stress factors. There are several vaccines available (ATCvet codes: inactivated, live, plus various combinations).
EHV-4 is an upper respiratory disease restricted to the infection of the respiratory tract epithelium and its associated lymph nodes. EHV 4 and its close relative EHV 1 are clinically and pathologically indistinguishable and are the primary pathogens that causing respiratory tract disease in young horses from weanling to 2 years of age. Incubation period of Equine Herpiesvirus is 2-10 days. Symptoms include fever (38.9-41.7°C) , loss of appetite, and a nasal discharge giving it the nickname “snots”. Without antibiotic treatment, the damage to the respiratory mucosal barrier predisposes infected horses to secondary infections and the involvement of the lower airways ( ex. bronchiolitis or pneumonia); Increasing the duration, severity and the mortality of the disease. EHV-4 rarely causes abortion in infected pregnant mare’s unlike its EHV-1 counterpart. Although there is no specific treatment for the disease once a horse is infected, vaccination against EHV-1 and EHV-4 is recommended as part of preventative herd health for those at high risk of infection. Multiple vaccines are available ( Duvaxyn EHV1,4, EquiGuard, EquiVac EHV-1/4, etc. ), most in an inactivated virus form.
The Equine Herpiesvirus occupies the horse in such a way that allows post infection viral persistency over the lifetime of an animal. These carrier horses may comprise up to half of a given horse population. Therefore management practices are recommended for controlling and managing EHV include isolating incoming horses for 3-4 wks before co-mingling with resident horses and pregnant mares, reducing stress to prevent the reappearance of a latent virus and if there is an appearance of EHV affected horses should be isolated, and disinfection of the contaminated premise should commence (The EHV has a large genome (150 kb) which is enclosed in a relatively fragile capsule. This limits their survival in the external environment and makes them highly susceptible to common disinfectants. ). After an outbreak no horse should leave the premise for three weeks after the final clinical case recovers. Effective prevention measures, quick diagnosis, therapeutic intervention and the ability to control the spread in the case of an outbreak all allow for the management of EHV.
Virus
A virus is a small infectious agent that can replicate only inside the living cells of organisms. Viruses infect all types of organisms, from animals and plants to bacteria and archaea...
of the family Herpesviridae
Herpesviridae
The Herpesviridae are a large family of DNA viruses that cause diseases in animals, including humans. The members of this family are also known as herpesviruses. The family name is derived from the Greek word herpein , referring to the latent, recurring infections typical of this group of viruses...
that cause rhinopneumonitis in horse
Horse
The horse is one of two extant subspecies of Equus ferus, or the wild horse. It is a single-hooved mammal belonging to the taxonomic family Equidae. The horse has evolved over the past 45 to 55 million years from a small multi-toed creature into the large, single-toed animal of today...
s. It is the most important viral cause of respiratory infection in foals. Like other herpes viruses, EHV-4 causes a lifelong latent infection in affected animals. These horses are usually the source for new infection for foals over two months old, weanlings, and yearlings. Symptoms include fever, loss of appetite, and discharge from the nose. Most infected animals recover in one to three weeks, but death can occur in environments with overcrowding and other stress factors. There are several vaccines available (ATCvet codes: inactivated, live, plus various combinations).
EHV-4 is an upper respiratory disease restricted to the infection of the respiratory tract epithelium and its associated lymph nodes. EHV 4 and its close relative EHV 1 are clinically and pathologically indistinguishable and are the primary pathogens that causing respiratory tract disease in young horses from weanling to 2 years of age. Incubation period of Equine Herpiesvirus is 2-10 days. Symptoms include fever (38.9-41.7°C) , loss of appetite, and a nasal discharge giving it the nickname “snots”. Without antibiotic treatment, the damage to the respiratory mucosal barrier predisposes infected horses to secondary infections and the involvement of the lower airways ( ex. bronchiolitis or pneumonia); Increasing the duration, severity and the mortality of the disease. EHV-4 rarely causes abortion in infected pregnant mare’s unlike its EHV-1 counterpart. Although there is no specific treatment for the disease once a horse is infected, vaccination against EHV-1 and EHV-4 is recommended as part of preventative herd health for those at high risk of infection. Multiple vaccines are available ( Duvaxyn EHV1,4, EquiGuard, EquiVac EHV-1/4, etc. ), most in an inactivated virus form.
The Equine Herpiesvirus occupies the horse in such a way that allows post infection viral persistency over the lifetime of an animal. These carrier horses may comprise up to half of a given horse population. Therefore management practices are recommended for controlling and managing EHV include isolating incoming horses for 3-4 wks before co-mingling with resident horses and pregnant mares, reducing stress to prevent the reappearance of a latent virus and if there is an appearance of EHV affected horses should be isolated, and disinfection of the contaminated premise should commence (The EHV has a large genome (150 kb) which is enclosed in a relatively fragile capsule. This limits their survival in the external environment and makes them highly susceptible to common disinfectants. ). After an outbreak no horse should leave the premise for three weeks after the final clinical case recovers. Effective prevention measures, quick diagnosis, therapeutic intervention and the ability to control the spread in the case of an outbreak all allow for the management of EHV.