Epi-lipoxin
Encyclopedia
Epi-lipoxins are the 5R-epimers
of lipoxin
s.
These nonclassic eicosanoid
s are formed in vivo, in the presence of aspirin
. They play a counter-regulatory role in inflammation
, serving as a stop signal.
Epimer
In chemistry, epimers are diastereomers that differ in configuration of only one stereogenic center. Diastereomers are a class of stereoisomers that are non-superposable, non-mirror images of one another....
of lipoxin
Lipoxin
Lipoxins are a series of anti-inflammatory mediators. Lipoxins are short lived endogenously produced nonclassic eicosanoids whose appearance in inflammation signals the resolution of inflammation....
s.
These nonclassic eicosanoid
Nonclassic eicosanoid
Nonclassic eicosanoids are biologically active signaling molecules made by oxygenation of twenty-carbon fatty acids other than the classic eicosanoids.-Terminology:"Eicosanoid" is the collective...
s are formed in vivo, in the presence of aspirin
Aspirin
Aspirin , also known as acetylsalicylic acid , is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. It was discovered by Arthur Eichengrun, a chemist with the German company Bayer...
. They play a counter-regulatory role in inflammation
Inflammation
Inflammation is part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Inflammation is a protective attempt by the organism to remove the injurious stimuli and to initiate the healing process...
, serving as a stop signal.