EMR3
Encyclopedia
EGF-like module-containing mucin-like hormone receptor-like 3 is a protein
that in humans is encoded by the EMR3 gene
.
G protein-coupled receptor
family expressed predominantly by cells of the immune system
. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF
)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 (EMR2
) on chromosome 19. This protein may play a role in myeloid
-myeloid interactions during immune and inflammatory responses.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the EMR3 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Function
This gene encodes a member of the class BSecretin receptor family
Secretin family of 7 transmembrane receptors is a family of evolutionarily related proteins.This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors...
G protein-coupled receptor
G protein-coupled receptor
G protein-coupled receptors , also known as seven-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein-linked receptors , comprise a large protein family of transmembrane receptors that sense molecules outside the cell and activate inside signal...
family expressed predominantly by cells of the immune system
Immune system
An immune system is a system of biological structures and processes within an organism that protects against disease by identifying and killing pathogens and tumor cells. It detects a wide variety of agents, from viruses to parasitic worms, and needs to distinguish them from the organism's own...
. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF
EGF-like domain
EGF-like domain is an evolutionary conserved protein domain, of about thirty to forty amino-acid residues long, which was found in a large number of mostly animal proteins. All these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted...
)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 (EMR2
EMR2
EGF-like module-containing mucin-like hormone receptor-like 2 is a protein that in humans is encoded by the EMR2 gene. EMR2 has also been designated as CD312 .-Further reading:...
) on chromosome 19. This protein may play a role in myeloid
Myeloid
The term myeloid suggests an origin in the bone marrow or spinal cord, or a resemblance to the marrow or spinal cord.In hematopoiesis, the term "myeloid cell" is used to describe any leukocyte that is not a lymphocyte...
-myeloid interactions during immune and inflammatory responses.