Dual-specificity kinase
Encyclopedia
In biochemistry
, a dual-specificity kinase is a kinase
that can act as both tyrosine kinase
and serine/threonine kinase
.
MEK
s, involved in MAP pathways, are principal examples of dual-specificity kinases. Other common examples include:
The systematic name of this enzyme class is ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating).
Biochemistry
Biochemistry, sometimes called biological chemistry, is the study of chemical processes in living organisms, including, but not limited to, living matter. Biochemistry governs all living organisms and living processes...
, a dual-specificity kinase is a kinase
Kinase
In chemistry and biochemistry, a kinase is a type of enzyme that transfers phosphate groups from high-energy donor molecules, such as ATP, to specific substrates, a process referred to as phosphorylation. Kinases are part of the larger family of phosphotransferases...
that can act as both tyrosine kinase
Tyrosine kinase
A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell. It functions as an "on" or "off" switch in many cellular functions....
and serine/threonine kinase
Serine/threonine-specific protein kinase
Serine/threonine protein kinases phosphorylate the OH group of serine or threonine .At least 125 of the 500+ human protein kinases are serine/threonine kinases .-Regulation:...
.
MEK
MEK
MEK or Mek may refer to:* In chemistry and industry methyl ethyl ketone, a solvent, used also to weld some plastics* The Iranian guerilla-cum-opposition group Mujahideen-e Khalq* Mek, a comic mini series by Warren Ellis...
s, involved in MAP pathways, are principal examples of dual-specificity kinases. Other common examples include:
- ADK1
- Arabidopsis dual specificity kinase 1
- CLK1CLK1Dual specificity protein kinase CLK1 is an enzyme that in humans is encoded by the CLK1 gene.-Further reading:...
, CLK2CLK2Dual specificity protein kinase CLK2 is an enzyme that in humans is encoded by the CLK2 gene.-Further reading:...
, CLK3, CLK4 - DSTYK
- DYR1A, DYR1B, DYRK2DYRK2Dual specificity tyrosine-phosphorylation-regulated kinase 2 is an enzyme that in humans is encoded by the DYRK2 gene.-Further reading:...
, DYRK3DYRK3Dual specificity tyrosine-phosphorylation-regulated kinase 3 is an enzyme that in humans is encoded by the DYRK3 gene.-Further reading:...
, DYRK4 - Mps1p
- TESK1TESK1Dual specificity testis-specific protein kinase 1 is an enzyme that in humans is encoded by the TESK1 gene.-Interactions:TESK1 has been shown to interact with YWHAB and SPRY4.-Further reading:...
, TESK2TESK2Dual specificity testis-specific protein kinase 2 is an enzyme that in humans is encoded by the TESK2 gene.-Further reading:... - TTKTTK (gene)Dual specificity protein kinase TTK is an enzyme that in humans is encoded by the TTK gene.-Further reading:...
The systematic name of this enzyme class is ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating).