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The Certain Safety Factor is the ratio of the lethal dose
Lethal dose

A lethal dose is an indication of the lethality of a given substance or type of radiation. Because resistance varies from one individual to another, the 'lethal dose' represents a dose at which a given percentage of subjects will die....
 to 1% of population to the effective dose
Effective dose

An effective dose in pharmacology is the amount of medication that produces a therapeutic response in 50% of the people taking it, sometimes also called ED-50....
 to 99% of the population (LD1/ED99). This is a better safety index than the LD50 for materials that have both desirable and undesirable effects, because it factors in the ends of the spectrum where doses may be necessary to produce a response in one person but can, at the same dose, be lethal in another.







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The Certain Safety Factor is the ratio of the lethal dose
Lethal dose

A lethal dose is an indication of the lethality of a given substance or type of radiation. Because resistance varies from one individual to another, the 'lethal dose' represents a dose at which a given percentage of subjects will die....
 to 1% of population to the effective dose
Effective dose

An effective dose in pharmacology is the amount of medication that produces a therapeutic response in 50% of the people taking it, sometimes also called ED-50....
 to 99% of the population (LD1/ED99). This is a better safety index than the LD50 for materials that have both desirable and undesirable effects, because it factors in the ends of the spectrum where doses may be necessary to produce a response in one person but can, at the same dose, be lethal in another.

See also

  • Therapeutic index
    Therapeutic index

    The therapeutic index , is a comparison of the amount of a therapeutic agent that causes the therapeutic effect to the amount that causes toxic effects....
  • Effective dose
    Effective dose

    An effective dose in pharmacology is the amount of medication that produces a therapeutic response in 50% of the people taking it, sometimes also called ED-50....
  • IC50
    IC50

    The half maximal inhibitory concentration is a measure of the effectiveness of a compound in inhibiting biological or biochemical function. Often, the compound in question is a drug candidate....
  • LD50
    LD50

    In toxicology, the median lethal dose, LD50 , or LCt50 of a toxic substance or radiation is the Dose required to kill half the members of a tested population....
  • EC50
    EC50

    The term half maximal effective concentration refers to the concentration of a drug or antibody which induces a response halfway between the baseline and maximum....