CP-532,903
Encyclopedia
CP-532,903 is a selective adenosine A3
subtype receptor agonist
. It has antiinflammatory effects and has been shown to reduce superoxide
generation in damaged tissues, and protects against tissue damage following myocardial ischemia
, mediated via an interaction with ATP-sensitive potassium channels.
Adenosine A3 receptor
The adenosine A3 receptor, also known as ADORA3, is an adenosine receptor, but also denotes the human gene encoding it.- Function :Adenosine A3 receptors are G protein-coupled receptors that couple to Gi/Gq and are involved in a variety of intracellular signaling pathways and physiological functions...
subtype receptor agonist
Agonist
An agonist is a chemical that binds to a receptor of a cell and triggers a response by that cell. Agonists often mimic the action of a naturally occurring substance...
. It has antiinflammatory effects and has been shown to reduce superoxide
Superoxide
A superoxide, also known by the obsolete name hyperoxide, is a compound that possesses the superoxide anion with the chemical formula O2−. The systematic name of the anion is dioxide. It is important as the product of the one-electron reduction of dioxygen O2, which occurs widely in nature...
generation in damaged tissues, and protects against tissue damage following myocardial ischemia
Myocardial ischemia
Myocardial ischemia is an imbalance between myocardial oxygen supply and demand. Left untreated, it results in angina pectoris, myocardial stunning, myocardial hibernation, ischemic preconditioning, postconditioning, or under the most severe instances, acute coronary syndrome and myocardial...
, mediated via an interaction with ATP-sensitive potassium channels.