CFU-GEMM
Encyclopedia
CFU-GEMM is a colony forming unit that generates myeloid
cells.
CFU-GEMM cells are multipotential progenitor cell
s.
The "GEMM" stands for ""granulocyte
, erythrocyte, monocyte
, megakaryocyte
".
CFU-GEMM gives rise to CFU-GM
.
It has been suggested that eosinophils do not derive from the common myeloid progenitor.
Myeloid
The term myeloid suggests an origin in the bone marrow or spinal cord, or a resemblance to the marrow or spinal cord.In hematopoiesis, the term "myeloid cell" is used to describe any leukocyte that is not a lymphocyte...
cells.
CFU-GEMM cells are multipotential progenitor cell
Progenitor cell
A progenitor cell is a biological cell that, like a stem cell, has a tendency to differentiate into a specific type of cell, but is already more specific than a stem cell and is pushed to differentiate into its "target" cell...
s.
The "GEMM" stands for ""granulocyte
Granulocyte
Granulocytes are a category of white blood cells characterized by the presence of granules in their cytoplasm. They are also called polymorphonuclear leukocytes because of the varying shapes of the nucleus, which is usually lobed into three segments...
, erythrocyte, monocyte
Monocyte
Monocytes are a type of white blood cell and are part of the innate immune system of vertebrates including all mammals , birds, reptiles, and fish. Monocytes play multiple roles in immune function...
, megakaryocyte
Megakaryocyte
The megakaryocyte is a bone marrow cell responsible for the production of blood thrombocytes , which are necessary for normal blood clotting...
".
CFU-GEMM gives rise to CFU-GM
CFU-GM
CFU-GM is a colony forming unit. It is derived from CFU-GEMM.The "GM" stands for "granulocyte, monocyte".It is the precursor for monoblasts and myeloblasts....
.
It has been suggested that eosinophils do not derive from the common myeloid progenitor.