Transmembrane receptors are integral membrane proteins, which reside and operate typically within a cell's plasma membrane, but also in the biological membrane of some subcellular compartments and organelles.... expressed on cells of myeloid
Myeloid
The term myeloid suggests an origin in the bone marrow or spinal cord, or a resemblance to the marrow or spinal cord.In hematopoiesis, the term "myeloid cell" is used to describe any leukocyte that is not a lymphocyte.... lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells.
It binds sialic acids, therefore is a member of the SIGLEC
SIGLEC
SIGLECs, short for sialic acid binding Ig-like lectins are cell surface receptors and members of the immunoglobulin superfamily that recognize sugars.... family of lectin
Lectin
Lectins are sugar-binding proteins which are highly specific for their sugar moieties. They typically play a role in biological recognition phenomena involving cells and proteins.... s.
Transmembrane receptors are integral membrane proteins, which reside and operate typically within a cell's plasma membrane, but also in the biological membrane of some subcellular compartments and organelles.... expressed on cells of myeloid
Myeloid
The term myeloid suggests an origin in the bone marrow or spinal cord, or a resemblance to the marrow or spinal cord.In hematopoiesis, the term "myeloid cell" is used to describe any leukocyte that is not a lymphocyte.... lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells.
It binds sialic acids, therefore is a member of the SIGLEC
SIGLEC
SIGLECs, short for sialic acid binding Ig-like lectins are cell surface receptors and members of the immunoglobulin superfamily that recognize sugars.... family of lectin
Lectin
Lectins are sugar-binding proteins which are highly specific for their sugar moieties. They typically play a role in biological recognition phenomena involving cells and proteins.... s.
An immunoglobulin fold is a common all-? protein fold that consists of a 2-layer sandwich of ~7 antiparallel beta sheet arranged in two beta sheet.... (one IgV and one IgC2 domain), placing CD33 within the immunoglobulin superfamily
Immunoglobulin superfamily
The immunoglobulin superfamily is a large group of cell surface and soluble proteins that are involved in the recognition, binding, or cell adhesion processes of Cell .... . The intracellular portion of CD33 contains immunoreceptor tyrosine-based inhibitory motif
Immunoreceptor tyrosine-based inhibitory motif
An immunoreceptor tyrosine-based inhibition motif , is a conserved sequence of amino acids that is found in the cytoplasmic tails of many inhibitory immune receptor of the immune system.... s (ITIMs) that are implicated in inhibition of cellular activity.
Gemtuzumab ozogamicin is a monoclonal antibody used to treat acute myelogenous leukemia.It is a monoclonal antibody to CD33 linked to a cytotoxic agent, calicheamicin.... , a monoclonal antibody-based treated for acute myeloid leukemia
Acute myeloid leukemia
Acute myeloid leukemia , also known as acute myelogenous leukemia, is a cancer of the myeloid line of white blood cells, characterized by the rapid proliferation of abnormal cells which accumulate in the bone marrow and interfere with haematopoiesis.... .
