Bone cell
Encyclopedia
There are five types of bone cells.
  • Osteoblast
    Osteoblast
    Osteoblasts are mononucleate cells that are responsible for bone formation; in essence, osteoblasts are specialized fibroblasts that in addition to fibroblastic products, express bone sialoprotein and osteocalcin.Osteoblasts produce a matrix of osteoid, which is composed mainly of Type I collagen...

    s - These are commonly called bone-forming cells. They secrete osteoid
    Osteoid
    In histology, osteoid is the unmineralized, organic portion of the bone matrix that forms prior to the maturation of bone tissue. Osteoblasts begin the process of forming bone tissue by secreting the osteoid as several specific proteins...

    , which forms the bone matrix. They also begin mieralization
    Mineralization (biology)
    In biology, mineralization refers to the process where an organic substance is converted to an inorganic substance.This may also be a normal biological process which takes place during the life of an organism such as the formation of bone tissue or egg shells, largely with calcium.This term may...

    , and are unable to divide.
  • Osteocyte
    Osteocyte
    An osteocyte, a star-shaped cell, is the most abundant cell found in compact bone. Cells contain a nucleus and a thin ring of cytoplasm. When osteoblasts become trapped in the matrix they secrete, they become osteocytes...

    s - A mature osteoblast which no longer secretes matrix, yet is surrounded by it. Maintains metabolism, and participates in nutrient/waste exchange via blood. Unable to divide.
  • Osteoclast
    Osteoclast
    An osteoclast is a type of bone cell that removes bone tissue by removing its mineralized matrix and breaking up the organic bone . This process is known as bone resorption. Osteoclasts were discovered by Kolliker in 1873...

    s - These function in resorption and degradation of existing bone, the opposite of osteoblasts. Monocytes (a type of white blood cell) fuse together to create these huge cells, which are concentrated in the endosteum
    Endosteum
    In anatomy the endosteum is a thin layer of connective tissue that lines the surface of the bony tissue that forms the medullary cavity of long bones. This endosteal surface is usually resorbed during long periods of malnutrition, resulting in less cortical thickness...

    .
  • Osteoprogenitors - Immature cells which differentiate
    Cellular differentiation
    In developmental biology, cellular differentiation is the process by which a less specialized cell becomes a more specialized cell type. Differentiation occurs numerous times during the development of a multicellular organism as the organism changes from a simple zygote to a complex system of...

     to make osteoblasts. May divide.
  • bone-lining- quiescent osteoblasts covering the bone


Although osteogenic or osteoprogenitor cells are commonly mentioned in bone literature, these do not appear to be a unique type of cell. Rather, osteoblasts derive from mesenchymal stem cell
Mesenchymal stem cell
Mesenchymal stem cells, or MSCs, are multipotent stem cells that can differentiate into a variety of cell types, including: osteoblasts , chondrocytes and adipocytes...

s, which have shown the ability to differentiate into chondrocyte
Chondrocyte
Chondrocytes are the only cells found in cartilage. They produce and maintain the cartilaginous matrix, which consists mainly of collagen and proteoglycans...

s and adipocyte
Adipocyte
However, in some reports and textbooks, the number of fat cell increased in childhood and adolescence. The total number is constant in both obese and lean adult...

s as well.

See also

  • Chondroblast
    Chondroblast
    A chondroblast is a cell which originates from a mesenchymal stem cell and forms chondrocytes, commonly known as cartilage cells. Chondroblasts that become embedded in the matrix are called chondrocytes. They lie in the space or lacunae present in the groups of two or more. The groups are formed by...

  • Epiphyseal plate
    Epiphyseal plate
    The epiphyseal plate is a hyaline cartilage plate in the metaphysis at each end of a long bone...

  • Mesenchymal stem cell
    Mesenchymal stem cell
    Mesenchymal stem cells, or MSCs, are multipotent stem cells that can differentiate into a variety of cell types, including: osteoblasts , chondrocytes and adipocytes...

  • Perichondrium
    Perichondrium
    The perichondrium is a layer of dense irregular connective tissue which surrounds the cartilage of developing bone. It consists of two separate layers: an outer fibrous layer and inner chondrogenic layer. The fibrous layer contains fibroblasts, which produce collagenous fibers. The chondrogenic...

  • Periosteum
    Periosteum
    Periosteum is a membrane that lines the outer surface of all bones, except at the joints of long bones. Endosteum lines the inner surface of all bones....

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