Autologous endometrial coculture

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Autologous endometrial coculture

Autologous Endometrial Coculture is a technique of assisted reproductive technology

Assisted reproductive technology

Assisted reproductive technology is a general term referring to methods used to achieve pregnancy by artificial or partially artificial means. It is reproductive technology used in infertility treatment, which is the only application routinely used today of reproductive technology....
. It involves placing a patient’s fertilized eggs on top of a layer of cells from her own uterine lining, creating a more natural environment for embryo development and maximizing the chance for an in vitro fertilization (IVF) pregnancy.

pical Coculture cycle consists of the following steps:
1.

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Autologous Endometrial Coculture is a technique of assisted reproductive technology

Assisted reproductive technology

How Coculture is performed

A typical Coculture cycle consists of the following steps:
1. Once a patient has been deemed an appropriate candidate for the procedure, she undergoes an endometrial biopsy

Biopsy

A biopsy is a medical test involving the removal of Cell_s or Biological tissues for examination. It is the removal of tissue from a living subject to determine the presence or extent of a disease....
during which a small piece of her uterine lining is removed.
2. The uterine lining sample is sent to a research lab, where it is treated, purified and frozen.
3. The patient then undergoes a typical IVF cycle and is given medication to stimulate egg growth in her ovaries.
4. The patient’s eggs are retrieved and mixed with the sperm

Spermatozoon

A sperm, from the ancient Greek word sp???a and and more commonly known as a sperm cell, is the ploidy cell that is the male gamete. It Fertilization an ovum to form a zygote....
. At this time, the lab begins thawing and growing her endometrial cells.
5. Once fertilization is confirmed, the patient’s embryo

Embryo

An embryo is a multicellular organism ploidy eukaryote in its earliest stage of development, from the time of first cell division until birth, Egg , or germination....
s are placed on top of her own (and now thawed) endometrial cells.
6. Over the next two days, the embryos are closely monitored for growth and development.
7. The patient’s embryos are transferred into her uterus for implantation and pregnancy

Pregnancy

Pregnancy is the carrying of one or more offspring, known as a fetus or embryo, inside the uterus of a female. In a pregnancy, there can be multiple gestations, as in the case of twins or Multiple birth....
.

The potential candidate

Coculture can be an effective treatment for patients who have failed previous IVF cycles or who have poor embryo quality.

Advantages

In addition to being noninvasive and relatively pain free, Coculture can be performed during a short office visit. The procedure also can improve embryo quality and stimulate embryo growth.

Risks

The risks of Coculture are minimal. The procedure has been performed in over 1000 patients with no reported detrimental effects on embryo growth. Complications involving uterine infection or damage caused by embryo biopsy are extremely rare.