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Addiction



 
 
The term "addiction" is used in many contexts to describe an obsession, compulsion, or excessive physical dependence
Physical dependence

Physical dependence refers to a state resulting from chronic use of a drug that has produced Tolerance and where negative physical symptoms of withdrawal result from abrupt discontinuation or dosage reduction....
 or psychological dependence, such as: drug addiction
Drug addiction

Drug addiction is widely considered a Pathology. The disorder of addiction involves the progression of acute drug use to the development of drug-seeking behavior, the vulnerability to relapse, and the decreased, slowed ability to respond to naturally rewarding stimuli....
, video game addiction, crime
Crime

Societies define Crime as the breach of one or more rules or laws for which some Government or force may ultimately prescribe a punishment.The word crime originates from the Latin crimen , from the Latin root cerno and Greek ????? = "I judge"....
, alcoholism
Alcoholism

Alcoholism is a term with multiple and sometimes conflicting definitions to describe the detrimental effects of alcohol intake.In common and historic usage, alcoholism refers to any condition that results in the continued consumption of alcoholic beverages despite health problems and negative social consequences....
, compulsive overeating, problem gambling, computer addiction
Computer addiction

Computer addiction, or more broadly computer overuse, is excessive or compulsive use of computers that interferes with daily life.The Diagnostic and Statistical Manual of Mental Disorders criteria for substance dependency have been used to argue that some individuals suffer from computer addiction....
, pornography
Pornography

Pornography or porn is the explicit depiction of sexual subject matter with the sole intention of sexually exciting the viewer. It is to a certain extent similar to erotica, which is the use of sexually arousing imagery....
 addiction, etc.

In medical terminology, an addiction is a state in which the body relies on a substance for normal functioning and develops physical dependence, as in drug addiction.






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Bayer Heroin Bottle
The term "addiction" is used in many contexts to describe an obsession, compulsion, or excessive physical dependence
Physical dependence

Physical dependence refers to a state resulting from chronic use of a drug that has produced Tolerance and where negative physical symptoms of withdrawal result from abrupt discontinuation or dosage reduction....
 or psychological dependence, such as: drug addiction
Drug addiction

Drug addiction is widely considered a Pathology. The disorder of addiction involves the progression of acute drug use to the development of drug-seeking behavior, the vulnerability to relapse, and the decreased, slowed ability to respond to naturally rewarding stimuli....
, video game addiction, crime
Crime

Societies define Crime as the breach of one or more rules or laws for which some Government or force may ultimately prescribe a punishment.The word crime originates from the Latin crimen , from the Latin root cerno and Greek ????? = "I judge"....
, alcoholism
Alcoholism

Alcoholism is a term with multiple and sometimes conflicting definitions to describe the detrimental effects of alcohol intake.In common and historic usage, alcoholism refers to any condition that results in the continued consumption of alcoholic beverages despite health problems and negative social consequences....
, compulsive overeating, problem gambling, computer addiction
Computer addiction

Computer addiction, or more broadly computer overuse, is excessive or compulsive use of computers that interferes with daily life.The Diagnostic and Statistical Manual of Mental Disorders criteria for substance dependency have been used to argue that some individuals suffer from computer addiction....
, pornography
Pornography

Pornography or porn is the explicit depiction of sexual subject matter with the sole intention of sexually exciting the viewer. It is to a certain extent similar to erotica, which is the use of sexually arousing imagery....
 addiction, etc.

In medical terminology, an addiction is a state in which the body relies on a substance for normal functioning and develops physical dependence, as in drug addiction. When the drug or substance on which someone is dependent is suddenly removed, it will cause withdrawal
Withdrawal

Withdrawal, also known as withdrawal/abstinence syndrome, refers to the characteristic signs and symptoms that appear when a drug that causes physical dependence is regularly used for a long time and then suddenly discontinued or decreased in dosage....
, a characteristic set of signs and symptoms. Addiction is generally associated with increased drug tolerance. In physiological terms, addiction is not necessarily associated with substance abuse
Substance abuse

Substance abuse is the overindulgence in and dependence of a drug or other chemical leading to effects that are detrimental to the individual's physical and mental health, or the Quality of life of others....
 since this form of addiction can result from using medication
Medication

A pharmaceutical drug, also referred to as medicine or medicament, can be loosely defined as any substance intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease....
 as prescribed by a doctor.

However, common usage of the term addiction has spread to include psychological dependence. In this context, the term is used in drug addiction and substance abuse
Substance abuse

Substance abuse is the overindulgence in and dependence of a drug or other chemical leading to effects that are detrimental to the individual's physical and mental health, or the Quality of life of others....
 problems, but also refers to behaviors that are not generally recognized by the medical community as problems of addiction, such as compulsive overeating.

The term addiction is also sometimes applied to compulsions that are not substance-related, such as problem gambling and computer addiction. In these kinds of common usages, the term addiction is used to describe a recurring compulsion
Compulsive behavior

Compulsive behavior is behavior which a person does compulsively, i.e., not because they enjoy it but because they feel they "have to". The two most common types of compulsions are seen in the following disorders:...
 by an individual to engage in some specific activity, despite harmful consequences to the individual's health, mental state or social life.

History of addiction models

The term "addiction" appeared as far back as at least 1599, when Shakespeare
William Shakespeare

William Shakespeare was an English people poet and playwright, widely regarded as the greatest writer in the English language and the world's preeminent dramatist....
 used it in the first scene of Henry V
Henry V (play)

Henry V is a history play by William Shakespeare, believed to be written in 1599. It is based on the life of King Henry V of England, and focuses on events immediately before and after the Battle of Agincourt during the Hundred Years' War....
; however it wasn't until 1906, in reference to opium
Opium

Opium is a narcotic formed from the latex released by lacerating the immature seed pods of Opium poppy . It contains up to 12% morphine, an opiate alkaloid, which is most frequently processed chemically to produce heroin for the illegal drug trade....
, that it began to be used regularly. There is also an isolated usage, recorded from 1779, referring to tobacco
Tobacco

Tobacco is an agricultural product processed from the fresh leaves of plants in the genus Nicotiana. It can be consumed, used as an organic pesticide, and in the form of nicotine tartrate it is used in some medicines....
. The first use of the adjective 'addict' (with the meaning of 'delivered, devoted') was in 1529 and comes from the Latin addictus, pp. of addicere ('deliver, yield, devote,' from ad-, 'to' + dicere, 'say, declare').

Prior to the latter half of the 20th Century, addiction was primarily a pharmacological term that referred to the process of developing drug tolerance so that more of a drug was required, more frequently, for the same effect to occur. However, with the founding of Alcoholics Anonymous
Alcoholics Anonymous

Alcoholics Anonymous is a worldwide fellowship of men and women who share a desire to stop drinking alcoholic beverage. AA suggests members completely abstain from alcohol, regularly attend meetings with other members, and follow its program to help each other with their common purpose; to help members "stay sober and help other alcoholics...
 in 1935, the allergy concept eventually morphed into the disease-model of addiction was proposed, based on the work of Dr. William Duncan Silkworth
William Duncan Silkworth

William Duncan Silkworth, M.D., was an United States medical doctor and specialist in the treatment of alcoholism. He was Director of the Charles B....
, and began to gather support in the professional community, amongst medical and social services workers, and amongst addicts themselves. The disease-model concept led to a definition of addiction based on the continued use of alcohol or drugs despite negative consequences for the user. This latter definition is now thought of as a disease state by the medical community. Morse and Flavin summarise the disease-model definition of addiction commonly utilized by treatment centers and substance abuse counselors:
Addiction is a primary, progressive, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and can sometimes be fatal. It is characterized by impaired control over use of the substance, preoccupation with the substance, use of the substance despite adverse consequences, and distortions in thinking.


In the latter half of the 20th Century, the twelve-step program
Twelve-step program

A twelve-step program is a set of guiding principles outlining a course of action for recovery from addiction, Compulsive behavior, or other behavioral problems....
 began to be applied to a wide range of problem behaviours, many never previously identified as addictions. For example, during this process the establishment of Overeaters Anonymous
Overeaters Anonymous

Overeaters Anonymous is a twelve-step program for people with problems related to food including, but not limited to, compulsive overeaters, those with binge eating disorder, Bulimia nervosa and Anorexia nervosa....
 in 1960 led to the identification of an associated concept of food addiction and the establishment of Sex and Love Addicts Anonymous
Sex and Love Addicts Anonymous

Sex and Love Addicts Anonymous is a twelve-step program for people recovering from sexual addiction and Codependence. SLAA was founded in Boston, Massachusetts in 1977, by a musician who was also a member of Alcoholics Anonymous ....
 in 1977 led to the identification of the concept of sexual addiction
Sexual addiction

Sexual addiction refers to a controversial phenomenon in which individuals report being unable to manage their sexual behavior. It has also been called "hypersexuality," "sexual dependency," and "sexual compulsivity." The existence of the condition is not universally accepted by sexologists, and there is debate about its etiology, nature, a...
. However, although these terms are widely used in the recovery movement, and by commentators on that movement, neither of them are widely accepted by members of the professional communities working in the fields of addiction.

In the 21st Century, attempts have been made to model addiction using the tools of economics
Economics

File:Ballard Farmers' Market - vegetables.jpgEconomics is the Social sciences that studies the Production theory basics, Distribution , and Consumption of Good and Service ....
, for instance, by calculating the elasticity
Elasticity (economics)

In economics, elasticity is the ratio of the percent change in one variable to the percent change in another variable. It is a tool for measuring the responsiveness of a function to changes in parameters in a relative way....
 of addictive goods and determining to what extent present income
Income

Income, refers to consumption opportunity gained by an entity within a specified time frame, which is generally expressed in monetary terms. However, for households and individuals, "income is the sum of all the wages, salaries, profits, interests payments, rents and other forms of earnings received......
 and consumption
Consumption (economics)

Consumption is a common concept in economics, and gives rise to derived concepts such as consumer debt. Generally consumption is defined by opposition to Production theory basics....
 has on future consumption. In general, most modern economists identify 3 models of addiction when analyzing patterns for policy research. These are:

- Myopic/Naive: This model essentially stipulates that addicts are characterized by near-sighted behavior and are wholly incapable of ascertaining the potential implications of their behavior. Therefore, under this model, demand for whatever the addict is addicted to would be totally inelastic, implying that the addict is unable to even slightly reduce consumption regardless of cost.

- Rational time-consistent: Under this model, the addict is assumed to be perfectly aware of future consequences of their behavior and is assumed to have fully considered all benefits and costs of their actions. Under this model, the elasticity of demand would be very high (at or nearing 1), implying that the addict will almost certainly change their behavior in response to price, since a high price may outweigh potential benefits.

- Time-inconsistent (as well as imperfectly rational): Under this model, the addict is assumed to be capable of some level of analysis of the benefits and costs of their behavior, but may not be able to act on the conclusions of this analysis due to physical dependencies and/or insufficient "willpower". The essence of this model is an attempt to classify typical behavior by which most addicts wish they could quit, indicating rationality and proper benefit/cost analysis, but are still unable to. Under this model, there is a moderate level of elasticity indicating some but not perfect responsiveness to price.

Definition

Not all doctors agree on the exact nature of addiction or dependency however the biopsychosocial model is generally accepted in scientific fields as the most comprehensive theorem for addiction. Historically, addiction has been defined with regard solely to psychoactive substances (for example alcohol
Alcoholism

Alcoholism is a term with multiple and sometimes conflicting definitions to describe the detrimental effects of alcohol intake.In common and historic usage, alcoholism refers to any condition that results in the continued consumption of alcoholic beverages despite health problems and negative social consequences....
, tobacco
Tobacco smoking

Tobacco smoking is the inhalation of smoke from burned dried or cured leaves of the tobacco plant, most often in the form of a cigarette. People may smoke casually for pleasure, habitually to satisfy an addiction to the nicotine present in tobacco and to the act of smoking, or in response to social pressure....
 and other drugs
Drug addiction

Drug addiction is widely considered a Pathology. The disorder of addiction involves the progression of acute drug use to the development of drug-seeking behavior, the vulnerability to relapse, and the decreased, slowed ability to respond to naturally rewarding stimuli....
) which cross the blood-brain barrier
Blood-brain barrier

The blood-brain barrier is a metabolic or cellular structure in the central nervous system that restricts the passage of various chemical substances and microscopic objects between the bloodstream and the neural tissue itself, while still allowing the passage of substances essential to metabolism function ....
 once ingested, temporarily altering the chemical milieu of the brain. However, "studies on phenomenology, family history, and response to treatment suggest that intermittent explosive disorder
Intermittent explosive disorder

Intermittent Explosive Disorder is a behavioral disorder characterized by extreme expressions of anger, often to the point of uncontrollable rage, that are disproportionate to the situation at hand....
, kleptomania
Kleptomania

Kleptomania is the condition of not being able to resist the urge to collect or hoard things. People with this disorder are compelled to steal things, generally things of little or no value, such as pens, paper clips, tape, small toys....
, pathological gambling, pyromania
Pyromania

Pyromania, a type of mania, is an impulse to deliberately start fires to relieve tension and typically includes feelings of gratification or relief afterward....
, and trichotillomania
Trichotillomania

Trichotillomania , or "trich" as it is commonly known, is an impulse control disorder or form of self-injury characterized by the repeated urge to pull out scalp hair, eyelashes, facial hair, nose hair, pubic hair, eyebrows or other body hair, sometimes resulting in noticeable bald patches....
 may be related to mood disorders, alcohol and psychoactive substance abuse
Substance abuse

Substance abuse is the overindulgence in and dependence of a drug or other chemical leading to effects that are detrimental to the individual's physical and mental health, or the Quality of life of others....
, and anxiety disorders (especially obsessive-compulsive disorder
Obsessive-compulsive disorder

Obsessive-compulsive disorder is a mental disorder most commonly characterized by Intrusive thoughts, repetitive thoughts resulting in compulsive behaviors and mental acts that the person feels driven to perform, according to rules that must be applied rigidly, aimed at reducing anxiety by preventing some dreaded event or by resolving a more...
)." However, such disorders are classified by the American Psychological Association
American Psychological Association

The American Psychological Association is a professional organization representing psychology in the United States, with around 148,000 members and an annual budget of around $70m....
 as impulse control disorder
Impulse control disorder

Impulse control disorder is a set of psychiatric disorders including intermittent explosive disorder , kleptomania , pathological gambling, pyromania , trichotillomania and dermatillomania ....
s and therefore not as addictions.

Many people, both psychology professionals and laypersons, now feel that there should be accommodation made to include psychological dependency on such things as gambling
Gambling

Gambling is the wikt:wager#Verb of money or something of material Value on an event with an uncertain outcome with the primary intent of winning additional money and/or material goods....
, food
Overeating

Overeating generally refers to the long-term consumption of excess food in relation to the energy that an organism expends , leading to weight gain and often obesity....
, sex
Sexual addiction

Sexual addiction refers to a controversial phenomenon in which individuals report being unable to manage their sexual behavior. It has also been called "hypersexuality," "sexual dependency," and "sexual compulsivity." The existence of the condition is not universally accepted by sexologists, and there is debate about its etiology, nature, a...
, pornography
Pornography addiction

Pornography addiction, or more broadly overuse of pornography, is excessive pornography use that interferes with daily life.There is no diagnosis of pornography addiction in the current DSM....
, computers
Computer addiction

Computer addiction, or more broadly computer overuse, is excessive or compulsive use of computers that interferes with daily life.The Diagnostic and Statistical Manual of Mental Disorders criteria for substance dependency have been used to argue that some individuals suffer from computer addiction....
, work
Workaholic

A workaholic, colloquially, is a person who is Addiction to work .The phrase does not always imply that the person actually enjoys their work, but rather simply feels compelled to do it....
, exercise, spiritual obsession (as opposed to religious devotion), cutting and shopping
Shopping

Shopping is the examining of goods or Service from retailers with intent to Trade at that time. Shopping is the activity of selection and/or purchase....
 so these behaviors count as 'addictions' as well and cause guilt
Guilt

Guilt is a cognitive or an emotional experience that occurs when a person understanding or belief - whether justified or not - that he or she has violated a Morality standard, and is responsible for that violation....
, shame
Shame

Shame is, variously, an Affect_, emotion, cognition, state_of_being. The roots of the word shame are thought to derive from an older word meaning to cover; as such, covering oneself, literally or figuratively, is a natural expression of shame....
, fear
Fear

Fear is an emotional response to threats and danger. It is a basic survival mechanism occurring in response to a specific stimulus, such as pain or the threat of pain....
, hopelessness, failure
Failure

Failure in general refers to the state or condition of not meeting a desirable or intended objective. It may be viewed as the opposite of success....
, rejection
Rejection

The word "rejection" was first used in 1415. The original meaning was "to throw" or "to throw back".Rejection may mean:* Social rejection, in psychology, an interpersonal situation that occurs when a person or group of people exclude an individual from a social relationship...
, anxiety
Anxiety

Anxiety is a psychological and physiological state characterized by cognitive, somatic, emotional, and behavioral components. These components combine to create an unpleasant feeling that is typically associated with uneasiness, fear, or worry....
, or humiliation
Humiliation

Humiliation is the abasement of pride, which creates mortification or leads to a state of being Humility or reduced to lowliness or submission....
 symptoms associated with, among other medical conditions, depression
Clinical depression

Major depressive disorder is a mental disorder characterized by a pervasive depression , low self-esteem, and anhedonia in normally enjoyable activities....
 and epilepsy
Epilepsy

Epilepsy is a common chronic neurological disorder characterized by recurrent unprovoked seizure s. These seizures are transient signs and/or symptoms of abnormal, excessive or synchronous neuronal activity in the brain....
. Although, the above mentioned are things or tasks which, when used or performed, do not fit into the traditional view of addiction and may be better defined as an obsessive-compulsive disorder
Obsessive-compulsive disorder

Obsessive-compulsive disorder is a mental disorder most commonly characterized by Intrusive thoughts, repetitive thoughts resulting in compulsive behaviors and mental acts that the person feels driven to perform, according to rules that must be applied rigidly, aimed at reducing anxiety by preventing some dreaded event or by resolving a more...
, withdrawal
Withdrawal

Withdrawal, also known as withdrawal/abstinence syndrome, refers to the characteristic signs and symptoms that appear when a drug that causes physical dependence is regularly used for a long time and then suddenly discontinued or decreased in dosage....
 symptoms may occur with abatement of such behaviors. It is said by those who adhere to a traditionalist view that these withdrawal-like symptoms are not strictly reflective of an addiction, but rather of a behavioral disorder. However, understanding of neural science, the brain, the nervous system, human behavior, and affective disorders has revealed "the impact of molecular biology in the mechanisms underlying developmental processes and in the pathogenesis of disease". The use of thyroid hormones as an effective adjunct treatment for affective disorders has been studied over the past three decades and has been confirmed repeatedly. Modern research into addiction is generally focused on Dopaminergic pathways
Dopaminergic pathways

Dopaminergic pathways are neural pathways in the brain which transmit the neurotransmitter dopamine from one region of the brain to another. There are eight dopaminergic neural pathway, but the four major ones are:...
. There is great and sometimes heated debate around the definition of addiction with parties falling into two main camps the Disease model of addiction
Disease model of addiction

The disease model of addiction describes an addiction as a lifelong disease involving biologic and environmental sources of origin. The traditional medical model of disease requires only that an abnormal condition be present that causes discomfort, dysfunction, or distress to the individual afflicted....
 and the behaviorists, explanations of various models can be found in the article on Drug rehabilitation
Drug rehabilitation

Drug rehabilitation is an umbrella term for the processes of medical and/or psychotherapeutic treatment, for dependency on Psychoactive drug such as alcoholic beverage, Medical prescription, and so-called street drugs such as cocaine, heroin or amphetamines....
.

Varied forms of addiction


In the United States
United States

The United States of America is a Federal government constitutional republic comprising U.S. state and a federal district. The country is situated mostly in central North America, where its Contiguous United States and Washington, D.C., the Capital districts and territories, lie between the Pacific Ocean and Atlantic Oceans, Borders of the U...
, physical dependence
Physical dependence

Physical dependence refers to a state resulting from chronic use of a drug that has produced Tolerance and where negative physical symptoms of withdrawal result from abrupt discontinuation or dosage reduction....
, abuse
Drug abuse

Drug abuse has a huge range of definitions related to taking a psychoactive drug or performance enhancing drug for a non-therapeutic or non-medical effect....
 of, and withdrawal
Withdrawal

Withdrawal, also known as withdrawal/abstinence syndrome, refers to the characteristic signs and symptoms that appear when a drug that causes physical dependence is regularly used for a long time and then suddenly discontinued or decreased in dosage....
 from drugs and other substances
Substance abuse

Substance abuse is the overindulgence in and dependence of a drug or other chemical leading to effects that are detrimental to the individual's physical and mental health, or the Quality of life of others....
 is outlined in the Diagnostic and Statistical Manual of Mental Disorders
Diagnostic and Statistical Manual of Mental Disorders

The Diagnostic and Statistical Manual of Mental Disorders is published by the American Psychiatric Association and provides diagnostic criteria for classification of mental disorders....
 (DSM-IV TR). It does not use the word 'addiction' at all. It has instead a section about Substance dependence
Substance dependence

According to the current Diagnostic and Statistical Manual of Mental Disorders , substance dependence is defined as:Substance dependence can be diagnosed with Physical dependence, evidence of tolerance or withdrawal, or without physiological dependence....
:
"Substance dependence When an individual persists in use of alcohol or other drugs despite problems related to use of the substance, substance dependence
Substance dependence

According to the current Diagnostic and Statistical Manual of Mental Disorders , substance dependence is defined as:Substance dependence can be diagnosed with Physical dependence, evidence of tolerance or withdrawal, or without physiological dependence....
 may be diagnosed. Compulsive and repetitive use may result in tolerance to the effect of the drug and withdrawal symptoms when use is reduced or stopped. This, along with Substance Abuse
Substance abuse

Substance abuse is the overindulgence in and dependence of a drug or other chemical leading to effects that are detrimental to the individual's physical and mental health, or the Quality of life of others....
 are considered Substance Use Disorders..."


Terminology has become quite complicated in the field. Pharmacologists continue to speak of addiction from a physiologic standpoint (some call this a physical dependence
Physical dependence

Physical dependence refers to a state resulting from chronic use of a drug that has produced Tolerance and where negative physical symptoms of withdrawal result from abrupt discontinuation or dosage reduction....
); psychiatrists refer to the disease state as psychological dependence; most other physicians refer to the disease as addiction. The field of psychiatry is now considering, as they move from DSM-IV to DSM-V, transitioning from "substance dependence" to "addiction" as terminology for the disease state.

The medical community now makes a careful theoretical distinction between physical dependence (characterized by symptoms of withdrawal
Withdrawal

Withdrawal, also known as withdrawal/abstinence syndrome, refers to the characteristic signs and symptoms that appear when a drug that causes physical dependence is regularly used for a long time and then suddenly discontinued or decreased in dosage....
) and psychological dependence (or simply addiction). Addiction is now narrowly defined as "uncontrolled, compulsive use"; if there is no harm being suffered by, or damage done to, the patient or another party, then clinically it may be considered compulsive, but to the definition of some it is not categorized as 'addiction'. In practice, the two kinds of addiction are not always easy to distinguish. Addictions often have both physical and psychological components.

There is also a lesser known situation called pseudo-addiction. A patient will exhibit drug-seeking behavior reminiscent of psychological addiction, but they tend to have genuine pain or other symptoms that have been under-treated. Unlike true psychological addiction, these behaviors tend to stop when the pain is adequately treated. The obsolete term physical addiction is deprecated, because of its connotations. In modern pain management with opioids physical dependence is nearly universal. While opiates are essential in the treatment of acute pain, the benefit of this class of medication in chronic pain is not well proven. Clearly, there are those who would not function well without opiate treatment; on the other hand, many states are noting significant increases in non-intentional deaths related to opiate use. High-quality, long-term studies are needed to better delineate the risks and benefits of chronic opiate use.

Physical dependency

Physical dependence
Physical dependence

Physical dependence refers to a state resulting from chronic use of a drug that has produced Tolerance and where negative physical symptoms of withdrawal result from abrupt discontinuation or dosage reduction....
 on a substance is defined by the appearance of characteristic withdrawal
Withdrawal

Withdrawal, also known as withdrawal/abstinence syndrome, refers to the characteristic signs and symptoms that appear when a drug that causes physical dependence is regularly used for a long time and then suddenly discontinued or decreased in dosage....
 symptoms when the substance is suddenly discontinued. Opiates, amphetamine
Amphetamine

Amphetamine and related drugs such as methamphetamine are a group of drugs that act by increasing levels of norepinephrine, serotonin, and dopamine in the brain....
s, benzodiazepine
Benzodiazepine

The benzodiazepines are a class of psychoactive drugs with varying hypnotic, sedative, anxiolytic , anticonvulsant, muscle relaxant and anterograde amnesia properties, which are mediated by slowing down the central nervous system....
s, barbiturate
Barbiturate

Barbiturates are medication that act as central nervous system depressants, and by virtue of this they produce a wide spectrum of effects, from mild sedation to anesthesia....
s, alcohol
Alcohol

In chemistry, an alcohol is any organic compound in which a hydroxyl Functional group is bound to a carbon atom of an alkyl or substituted alkyl group....
 and nicotine
Nicotine

Nicotine is an alkaloid found in the nightshade family of plants which constitutes approximately 0.6?3.0% of dry weight of tobacco, with biosynthesis taking place in the roots, and accumulating in the leaves....
 induce physical dependence. On the other hand, some categories of substances share this property and are still not considered addictive: cortisone
Cortisone

Cortisone is a steroid hormone. Chemically, it is a corticosteroid closely related to corticosterone....
, beta blocker
Beta blocker

Beta blockers are a class of medication used for various indications, but particularly for the management of cardiac arrhythmias, cardioprotection after myocardial infarction , and hypertension....
s and most antidepressant
Antidepressant

An antidepressant is a psychiatric medication used for alleviating major depressive disorder or dysthymia. Drug groups known as MAOIs, tricyclics, and second-generation antidepressants such as SSRIs, and serotonin-norepinephrine reuptake inhibitors are particularly associated with the term....
s are examples. So, while physical dependency can be a major factor in the psychology of addiction and most often becomes a primary motivator in the continuation of an addiction, the initial primary attribution of an addictive substance is usually its ability to induce pleasure, although with continued use the goal is not so much to induce pleasure as it is to relieve the anxiety caused by the absence of a given addictive substance, causing it to become used compulsively. An example of this is nicotine; A cigarette can be described as pleasurable, but is in fact fulfilling the physical addiction of the user, and therefore, is achieving pleasurable feelings relative to his/her previous state of physical withdrawal. Further, the physical dependency of the nicotine addict on the substance itself becomes an overwhelming factor in the continuation of use.

Some substances induce physical dependence or physiological tolerance
Physiological tolerance

In physiology, physiological tolerance or drug tolerance is commonly encountered in pharmacology, when a subject's reaction to a drug decreases so that larger doses are required to achieve the same effect....
 - but not addiction - for example many laxative
Laxative

Laxatives are foods, compounds, or drugs taken to induce bowel movements or to loosen the stool, most often taken to treat constipation. Certain stimulant, lubricant, and saline laxatives are used to evacuate the Colon for rectum and bowel examinations, and may be supplemented by enemas in that circumstance....
s, which are not psychoactive; nasal decongestant
Decongestant

A decongestant is a broad class of medications used to relieve nasal congestion. Generally, they work by reducing swelling of the mucous membranes in the nose passages....
s, which can cause rebound congestion if used for more than a few days in a row; and some antidepressants, most notably venlafaxine
Venlafaxine

Venlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor class first introduced by Wyeth in 1993. It is prescribed for the treatment of major depressive disorder and anxiety disorders, among other uses....
, paroxetine
Paroxetine

Paroxetine is a selective serotonin reuptake inhibitor antidepressant. It was released in 1992 by the pharmaceutical company GlaxoSmithKline. It is used to treat major depressive disorder, obsessive-compulsive disorder, panic disorder and social phobia disorders in adult Patient#Outpatient vs inpatient....
 and sertraline
Sertraline

Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor class. It was introduced to the market by Pfizer in 1991....
, as they have quite short half-lives
Half-life

The half-life of a quantity whose value decreases with time is the interval required for the quantity to decay to half of its initial value. The concept originated in describing how long it takes atoms to undergo radioactive decay but also applies in a wide variety of other situations....
, so stopping them abruptly causes a more rapid change in the neurotransmitter balance in the brain than many other antidepressants. Many non-addictive prescription drugs should not be suddenly stopped, so a doctor should be consulted before abruptly discontinuing them.

The speed with which a given individual becomes addicted to various substances varies with the substance, the frequency of use, the means of ingestion, the intensity of pleasure or euphoria, and the individual's genetic and psychological susceptibility. Some people may exhibit alcoholic tendencies from the moment of first intoxication, while most people can drink socially without ever becoming addicted. Opioid dependent individuals have different responses to even low doses of opioids than the majority of people, although this may be due to a variety of other factors, as opioid use heavily stimulates pleasure-inducing neurotransmitters in the brain. Nonetheless, because of these variations, in addition to the adoption and twin studies that have been well replicated, much of the medical community is satisfied that addiction is in part genetically moderated. That is, one's genetic makeup may regulate how susceptible one is to a substance and how easily one may become psychologically attached to a pleasurable routine.

Eating disorder
Eating disorder

An eating disorder is a compulsion to eat, or avoid eating, that negatively affects both one's physical and mental health. Eating disorders are all encompassing....
s are complicated pathological mental illnesses and thus are not the same as addictions described in this article. Eating disorders, which some argue are not addictions at all, are driven by a multitude of factors, most of which are highly different than the factors behind addictions described in this article. It has been reported, however, that patients with eating disorders can successfully be treated with the same non-pharmacological protocols used in patients with chemical addiction disorders. Gambling is another potentially addictive behavior with some biological overlap. Conversely gambling urges have emerged with the administration of Mirapex
Pramipexole

Pramipexole is a medication indicated for treating Parkinson's disease and restless legs syndrome . It is also sometimes used Off-label use as a treatment for cluster headache or to counteract the problems with low libido experienced by some users of SSRI antidepressant drugs....
 (pramipexole), a dopamine agonist
Agonist

An agonist is a term used to describe a type of Ligand or drug that binds and alters the activity of a Receptor . The ability to alter the activity of a receptor, also known as the agonist's efficacy is a property that distinguishes it from receptor antagonist, a type of receptor ligand which also binds a receptor but which does not alter t...
.

Psychological dependency

Psychological dependency is a dependency of the mind, and leads to psychological withdrawal symptoms (such as cravings, irritability
Irritability

Irritability is an excessive response to stimulus . Irritability takes many forms, from the contraction of a unicellular organism when touched, to complex reactions involving all the senses of higher animals....
, insomnia
Insomnia

Insomnia is a symptom of a sleep disorder characterized by persistent difficulty falling sleep or staying asleep despite the opportunity. Insomnia is a symptom, not a stand-alone diagnosis or a disease....
, depression
Depression (mood)

In the fields of psychology and psychiatry, the terms depression or depressed refer to sadness and other related emotions and behaviours. It can be thought of as either a disease or a syndrome....
, anorexia
Anorexia (symptom)

Anorexia is the decreased sensation of appetite. While the term in non-scientific publications is often used interchangeably with anorexia nervosa, many possible causes exist for a decreased appetite, some of which may be harmless, while others indicate a serious clinical condition, or pose a significant risk....
, etc). Addiction can in theory be derived from any rewarding behaviour, and is believed to be strongly associated with the dopaminergic system
Dopamine

Dopamine is a neurotransmitter occurring in a wide variety of animals, including both vertebrates and invertebrates. In the human brain, this phenethylamine functions as a neurotransmitter, activating the five types of dopamine receptors ? D1, D2, D3, D4 and D5, and their variants....
 of the brain
Brain

The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as cnidarian and echinoderm have a decentralized nervous system without a brain, while sponges lack any nervous system at all....
's reward system
Reward system

In neuroscience, the reward system is a collection of brain structures which attempts to regulate and control behavior by inducing pleasurable effects....
 (as in the case of cocaine
Cocaine

Cocaine is a crystalline tropane alkaloid that is obtained from the leaves of the coca plant. The name comes from "coca" in addition to the alkaloid suffix -ine, forming cocaine....
 and amphetamines). Some claim that it is a habitual
Habit (psychology)

Habits are routines of behavior that are repeated regularly, tend to occur subconsciously, without directly thinking Consciousness about them. Habitual behavior sometimes goes unnoticed in persons exhibiting them, because it is often unnecessary to engage in self-analysis when undertaking in routine tasks....
 means to avoid undesired activity, but typically it is only so to a clinical level in individuals who have emotional, social, or psychological dysfunctions
Mental illness

A mental disorder or mental illness is a psychological or behavioral pattern that occurs in an individual and is thought to cause distress or disability that is not expected as part of normal development or culture....
 (psychological addiction is defined as such), replacing normal positive stimuli not otherwise attained (see Rat Park
Rat Park

Rat Park was a study into drug addiction conducted in the 1970s by Canadian psychologist Bruce K. Alexander at Simon Fraser University in British Columbia, Canada....
 study).

A person who is physically dependent, but not psychologically dependent can have their dose slowly dropped until they are no longer dependent. However, if that person is psychologically dependent, they are still at serious risk for relapse into abuse and subsequent physical dependence.

Psychological dependence does not have to be limited only to substances; even activities and behavioral patterns can be considered addictions, if they become uncontrollable, e.g. problem gambling, Internet addiction
Internet addiction disorder

Internet addiction disorder , or more broadly Internet overuse, problematic computer use or pathological computer use is excessive computer use that interferes with daily life....
, computer addiction
Computer addiction

Computer addiction, or more broadly computer overuse, is excessive or compulsive use of computers that interferes with daily life.The Diagnostic and Statistical Manual of Mental Disorders criteria for substance dependency have been used to argue that some individuals suffer from computer addiction....
, sexual addiction
Sexual addiction

Sexual addiction refers to a controversial phenomenon in which individuals report being unable to manage their sexual behavior. It has also been called "hypersexuality," "sexual dependency," and "sexual compulsivity." The existence of the condition is not universally accepted by sexologists, and there is debate about its etiology, nature, a...
 / pornography addiction
Pornography addiction

Pornography addiction, or more broadly overuse of pornography, is excessive pornography use that interferes with daily life.There is no diagnosis of pornography addiction in the current DSM....
, eating
Eating disorder

An eating disorder is a compulsion to eat, or avoid eating, that negatively affects both one's physical and mental health. Eating disorders are all encompassing....
, self-injury, or work addiction
Workaholic

A workaholic, colloquially, is a person who is Addiction to work .The phrase does not always imply that the person actually enjoys their work, but rather simply feels compelled to do it....
.

Addiction and drug control legislation


Most countries have legislation which brings various drugs and drug-like substances under the control of licensing systems. Typically this legislation covers any or all of the opiates, amphetamines, cannabinoids
Cannabinoids

Cannabinoids are a group of terpenephenolic compounds present in Cannabis . The broader definition of cannabinoids refers to a group of substances that are structurally related to tetrahydrocannabinol or that bind to cannabinoid receptors....
, cocaine
Cocaine

Cocaine is a crystalline tropane alkaloid that is obtained from the leaves of the coca plant. The name comes from "coca" in addition to the alkaloid suffix -ine, forming cocaine....
, barbiturate
Barbiturate

Barbiturates are medication that act as central nervous system depressants, and by virtue of this they produce a wide spectrum of effects, from mild sedation to anesthesia....
s, hallucinogens (tryptamines, LSD
LSD

Lysergic acid diethylamide, LSD, LSD-25, or acid, is a semisynthetic psychedelic drug of the ergoline family. Its unusual psychological effects, which include visuals of colored patterns behind the eyes in the mind, a sense of time distorting, and crawling geometric patterns, have made it one of the most widely known psyched...
, phencyclidine
Phencyclidine

Phencyclidine , also known as angel dust, is a dissociative drug formerly used as an anesthesia agent, exhibiting hallucinogenic and neurotoxic effects....
(PCP
PCP

PCP may refer to:In Industry*Pentachlorophenol, a timber preservative, herbicide, insecticide, fungicide and algaecide.In medicine and pharmaceutics:...
), psilocybin
Psilocybin

Psilocybin is a psychedelic drug indole of the tryptamine family, found in psilocybin mushrooms. It is present in List of Psilocybin mushrooms of fungi, including those of the genus Psilocybe, such as Psilocybe cubensis and liberty cap , but also reportedly isolated from a dozen or so other genera....
) and a variety of more modern synthetic drugs, and unlicensed production, supply or possession may be a criminal offense.

Usually, however, drug classification under such legislation is not related simply to addictiveness. The substances covered often have very different addictive properties. Some are highly prone to cause physical dependency, whilst others rarely cause any form of compulsive need whatsoever. Typically nicotine (in the form of tobacco) is regulated extremely loosely, if at all, although it is well-known as one of the most addictive substances ever discovered.

Also, although the legislation may be justifiable on moral grounds to some, it can make addiction or dependency a much more serious issue for the individual. Reliable supplies of a drug become difficult to secure as illegally produced substances may have contaminants. Withdrawal from the substances or associated contaminants can cause additional health issues and the individual becomes vulnerable to both criminal abuse and legal punishment. Criminal elements that can be involved in the profitable trade of such substances can also cause physical harm to users.

Methods of care

Early editions of the American Psychiatric Association's
American Psychiatric Association

The American Psychiatric Association is the main professional organization of psychiatrists and trainee psychiatrists in the United States, and the most influential world-wide....
 Diagnostic and Statistical Manual of Mental Disorders
Diagnostic and Statistical Manual of Mental Disorders

The Diagnostic and Statistical Manual of Mental Disorders is published by the American Psychiatric Association and provides diagnostic criteria for classification of mental disorders....
 (DSM) described addiction as a physical dependency to a substance that resulted in withdrawal symptoms in its absence. Recent editions, including DSM-IV, have moved toward a diagnostic instrument that classifies such conditions as dependency, rather than addiction. The American Society of Addiction Medicine
American Society of Addiction Medicine

The American Society of Addiction Medicine is a professional organization for physicians who specialize in the treatment of addiction. It is based in Chevy Chase, Maryland, Maryland....
 recommends treatment for people with chemical dependency based on patient placement criteria (currently listed in PPC-2), which attempt to match levels of care according to clinical assessments in six areas, including:
  • Acute intoxication and/or withdrawal
    Withdrawal

    Withdrawal, also known as withdrawal/abstinence syndrome, refers to the characteristic signs and symptoms that appear when a drug that causes physical dependence is regularly used for a long time and then suddenly discontinued or decreased in dosage....
     potential
  • Biomedical conditions or complications
  • Emotional/behavioral conditions or complications
  • Treatment acceptance/resistance
  • Relapse
    Relapse

    A relapse occurs when a person is affected again by a condition that affected them in the past. This could be a medical or psychological condition such as Clinical depression, bipolar disorder, multiple sclerosis, cancer or an addiction to a drug abuse....
     potential
  • Recovery environment


Some medical systems, including those of at least 15 states of the United States, refer to an Addiction Severity Index to assess the severity of problems related to substance use. The index assesses problems in six areas: medical, employment/support, alcohol and other drug use, legal, family/social, and psychiatric.

While addiction or dependency is related to seemingly uncontrollable urges, and arguably could have roots in genetic predispositions, treatment of dependency is conducted by a wide range of medical and allied professionals, including Addiction Medicine
Addiction Medicine

Addiction medicine is a medical specialty that deals with the treatment of addiction. The specialty often crosses over into other areas, since various aspects of addiction fall within the fields of public health, psychiatry, and internal medicine, among others....
 specialists, psychiatrists, psychologists, and appropriately trained nurses, social workers, and counselors. Early treatment of acute withdrawal often includes medical detoxification, which can include doses of anxiolytic
Anxiolytic

An anxiolytic is a Medication prescribed for the treatment of symptoms of anxiety. Some anxiolytics have been shown to be useful in the treatment of anxiety disorders as have antidepressants such as the class of selective serotonin reuptake inhibitors ....
s or narcotics to reduce symptoms of withdrawal. An experimental drug, ibogaine
Ibogaine

Ibogaine is a naturally occurring Psychoactive drug compound found in a number of plants, principally in a member of the Apocynaceae known as iboga ....
, is also proposed to treat withdrawal and craving. Alternatives to medical detoxification include acupuncture detoxification
Acupuncture detoxification

Acupuncture detoxification is the use of auricular acupuncture to treat drug and alcohol addiction. Evidence supporting the use of auricular acupuncture to treat addictions is largely based on anecdotal and clinical reports....
. In chronic opiate addiction, a surrogate drug such as methadone
Methadone

Methadone is a synthetic opioid, used medically as an analgesic, antitussive and a maintenance drug addiction#Anti-addictive drugs for use in patients on opioids....
 is sometimes offered as a form of opiate replacement therapy
Opiate replacement therapy

Opiate Replacement Therapy is the medical procedure of replacing an Law opiate drug abuse such as heroin with a longer acting but less euphoric opiate, usually methadone or buprenorphine, that is taken under medical supervision....
. But treatment approaches universal focus on the individual's ultimate choice to pursue an alternate course of action.

Therapists often classify patients with chemical dependencies as either interested or not interested in changing. Treatments usually involve planning for specific ways to avoid the addictive stimulus, and therapeutic interventions intended to help a client learn healthier ways to find satisfaction. Clinical leaders in recent years have attempted to tailor intervention approaches to specific influences that affect addictive behavior, using therapeutic interviews in an effort to discover factors that led a person to embrace unhealthy, addictive sources of pleasure or relief from pain.

Treatment Modality Matrix
Behavioral PatternInterventionGoals
Low self-esteem
Self-esteem

In psychology, self-esteem reflects a person's overall evaluation or appraisal of his or her own worth.Self-esteem encompasses beliefs and emotions ....
, anxiety, verbal hostility
Relationship therapy, client centered approachIncrease self esteem, reduce hostility and anxiety
Defective personal constructs, ignorance of interpersonal meansCognitive restructuring including directive and group therapiesInsight
Focal anxiety such as fear of crowdsDesensitizationChange response to same cue
Undesirable behaviors, lacking appropriate behaviorsAversive conditioning, operant conditioning, counter conditioningEliminate or replace behavior
Lack of informationProvide informationHave client act on information
Difficult social circumstancesOrganizational intervention, environmental manipulation, family counselingRemove cause of social difficulty
Poor social performance, rigid interpersonal behaviorSensitivity training, communication training, group therapyIncrease interpersonal repertoire, desensitization to group functioning
Grossly bizarre behaviorMedical referralProtect from society, prepare for further treatment
Adapted from: Essentials of Clinical Dependency Counseling, Aspen Publishers


From the applied behavior analysis
Applied Behavior Analysis

Applied behavior analysis is the science of applying experimentally derived principles of behavior to improve socially significant behavior. ABA takes what we know about behavior and uses it to bring about positive change ....
 literature and the behavioral psychology literature several evidenced based intervention programs have emerged (1) behavioral maritial therapy (2) community reinforcement approach (3) cue exposure therapy and (4) contingency management strategies. In addition, the same author suggest that Social skills training adjunctive to inpatient treatment of alcohol dependence is probably efficacious.

Diverse explanations

Several explanations (or "models") have been presented to explain addiction. These divide, more or less, into the models which stress biological or genetic causes for addiction, and those which stress social or purely psychological causes. Of course there are also many models which attempt to see addiction as both a physiological and a psycho-social phenomenon.

  • The disease model of addiction
    Disease model of addiction

    The disease model of addiction describes an addiction as a lifelong disease involving biologic and environmental sources of origin. The traditional medical model of disease requires only that an abnormal condition be present that causes discomfort, dysfunction, or distress to the individual afflicted....
     holds that addiction is a disease
    Disease

    A disease or medical condition is an abnormal condition of an organism that impairs bodily functions, associated with specific symptoms and Medical signs....
    , coming about as a result of either the impairment of neurochemical
    Neurochemistry

    Neurochemistry is the specific study of neurochemicals, which include neurotransmitters and other molecules such as neuro-active drugs that influence neuron function....
     or behavioral processes, or of some combination of the two. Within this model, addictive disease is treated by specialists in Addiction Medicine
    Addiction Medicine

    Addiction medicine is a medical specialty that deals with the treatment of addiction. The specialty often crosses over into other areas, since various aspects of addiction fall within the fields of public health, psychiatry, and internal medicine, among others....
    . Within the field of medicine, the American Medical Association
    American Medical Association

    The American Medical Association , founded in 1847 and incorporated 1897, is the largest association of physicians and medical students in the United States....
    , National Association of Social Workers, and American Psychological Association
    American Psychological Association

    The American Psychological Association is a professional organization representing psychology in the United States, with around 148,000 members and an annual budget of around $70m....
     all have policies which are predicated on the theory that addictive processes represent a disease state. Most treatment approaches, as well, are based on the idea that dependencies are behavioral dysfunctions, and, therefore, contain, at least to some extent, elements of physical or mental disease. Organizations such as the American Society of Addiction Medicine
    American Society of Addiction Medicine

    The American Society of Addiction Medicine is a professional organization for physicians who specialize in the treatment of addiction. It is based in Chevy Chase, Maryland, Maryland....
     believe the research-based evidence for addiction's status as a disease is overwhelming.


  • The pleasure
    Pleasure

    Pleasure is commonly conceptualized as a positive experience, happiness, entertainment, enjoyment, ecstasy , and Euphoria . However, it is a difficult concept to define as the experience of pleasure differs from individual to individual....
     model
    proposed by professor Nils Bejerot
    Nils Bejerot

    Nils Bejerot was a Sweden psychiatry and criminology....
    . Addiction "is an emotional fixation (sentiment) acquired through learning, which intermittently or continually expresses itself in purposeful, stereotyped behavior with the character and force of a natural drive, aiming at a specific pleasure or the avoidance of a specific discomfort." "The pleasure mechanism may be stimulated in a number of ways and give rise to a strong fixation on repetitive behavior. Stimulation with drugs is only one of many ways, but one of the simplest, strongest,and often also the most destructive" "If the pleasure stimulation becomes so strong that it captivates an individual with the compulsion and force characteristic of natural drives, then there exists...an addiction" The pleasure model is used as one of the reason for zero tolerance
    Zero tolerance

    Zero tolerance is the concept of compelling persons in positions of authority, who might otherwise exercise their discretion in making subjective judgments regarding the severity of a given offense, to impose a pre-determined punishment regardless of individual culpability or "extenuating circumstances"....
     for use of illicit drugs


  • The genetic
    Genetics

    Genetics , a discipline of biology, is the science of heredity and Genetic variation in living organisms. The fact that living things inherit traits from their parents has been used since prehistoric times to improve crop plants and animals through selective breeding....
     model posits a genetic predisposition to certain behaviors. It is frequently noted that certain addictions "run in the family," and while researchers continue to explore the extent of genetic influence, many researchers argue that there is strong evidence that genetic predisposition is often a factor in dependency.


  • The experiential model devised by Stanton Peele
    Stanton Peele

    Stanton Peele, Ph. D., J.D., is a licensed psychologist, Lawyer, practicing psychotherapist and the author of books and articles on the subject of alcoholism, addiction and addiction treatment....
     argues that addictions occur with regard to experiences generated by various involvements, whether drug-induced or not. This model is in opposition to the disease, genetic, and neurobiological approaches. Among other things, it proposes that addiction is both more temporary or situational than the disease model claims, and is often outgrown through natural processes.


  • The opponent-process model generated by Richard Soloman states that for every psychological event A will be followed by its opposite psychological event B. For example, the pleasure one experiences from heroin
    Heroin

    Heroin is a opioid synthesized from morphine, a derivative of the opium poppy. It is the 3,6-acetate ester of morphine . The white crystalline form is commonly the hydrochloride salt diacetylmorphine hydrochloride, however heroin Freebase may also appear as a white powder....
     is followed by an opponent process of withdrawal, or the terror of jumping out of an airplane is rewarded with intense pleasure when the parachute opens. This model is related to the opponent process color theory. If you look at the color red then quickly look at a gray area you will see green. There are many examples of opponent processes in the nervous system including taste, motor movement, touch, vision, and hearing. Opponent-processes occurring at the sensory level may translate "down-stream" into addictive or habit-forming behavior.


  • The allostatic (stability through change) model generated by George Koob
    George Koob

    George F. Koob, Ph.D. is a Professor and Chair of the Committee on the Neurobiology of Addictive Disorders at The Scripps Research Institute and Adjunct Professor of Psychology and Psychiatry at the University of California, San Diego....
     and Michel LeMoal is a modification of the opponent process theory where continued use of a drug leads to a spiralling of uncontrolled use, negative emotional states and withdrawal and a shift into use to new allostatic set point which is lower than that maintained before use of the drug.


  • The cultural
    Culture

    Culture is difficult to define. For example, in 1952, Alfred Kroeber and Clyde Kluckhohn compiled a list of 164 definitions of "culture" in Culture: A Critical Review of Concepts and Definitions....
     model recognizes that the influence of culture is a strong determinant of whether or not individuals fall prey to certain addictions. For example, alcoholism is rare among Saudi Arabia
    Saudi Arabia

    The Kingdom of Saudi Arabia, KSA , is an Arab country and the largest country of the Arabian Peninsula. It is bordered by Jordan on the northwest, Iraq on the north and northeast, Kuwait, Qatar, Bahrain, and the United Arab Emirates on the east, Oman on the southeast, and Yemen on the south....
    ns, where obtaining alcohol is difficult and using alcohol is prohibited. In North America, on the other hand, the incidence of gambling
    Gambling

    Gambling is the wikt:wager#Verb of money or something of material Value on an event with an uncertain outcome with the primary intent of winning additional money and/or material goods....
     addictions soared in the last two decades of the 20th century, mirroring the growth of the gaming industry. Half of all patients diagnosed as alcoholic are born into families where alcohol is used heavily, suggesting that familiar influence, genetic factors, or more likely both, play a role in the development of addiction. What also needs to be noted is that when people don't gain a sense of moderation through their development they can be just as likely, if not more, to abuse substances than people born into alcoholic families.


  • The moral
    Moral

    A moral is a message conveyed or a lesson to be learned from a story or event. The moral may be left to the hearer, reader or viewer to determine for themselves, or may be explicitly encapsulated in a maxim....
     model states that addictions are the result of human weakness, and are defects of character
    Moral character

    Moral character or character is an evaluation of a particular individual's Morality qualities. The concept of character can imply a variety of attributes including the existence or lack of virtues such as integrity, courage, fortitude, honesty, and loyalty, or of good behaviors or Habit ....
    . Those who advance this model do not accept that there is any biological basis for addiction. They often have scant sympathy for people with serious addictions, believing either that a person with greater moral strength could have the force of will to break an addiction, or that the addict demonstrated a great moral failure in the first place by starting the addiction. The moral model is widely applied to dependency on illegal substances, perhaps purely for social or political reasons, but is no longer widely considered to have any therapeutic value. Elements of the moral model, especially a focus on individual choices, have found enduring roles in other approaches to the treatment of dependencies.


  • The habit
    Habit (psychology)

    Habits are routines of behavior that are repeated regularly, tend to occur subconsciously, without directly thinking Consciousness about them. Habitual behavior sometimes goes unnoticed in persons exhibiting them, because it is often unnecessary to engage in self-analysis when undertaking in routine tasks....
     model or "life-process model
    Life-process model of addiction

    The life-process model of addiction is the view that addiction is not a disease but rather a Habit response and a source of gratification and security that can be understood only in the context of societys and experiences....
    " proposed by Thomas Szasz
    Thomas Szasz

    Thomas Stephen Szasz is a psychiatrist and academic. He is Professor Emeritus of Psychiatry at the State University of New York Health Science Center in Syracuse, New York, New York....
     questions the very concept of "addiction." He argues that addiction is a metaphor, and that the only reason to make the distinction between habit and addiction "is to persecute somebody." However, the nature of this metaphor is unclear, and the list of groups that rejects Szasz's opinion that mental illness is a myth includes the American Psychiatric Association
    American Psychiatric Association

    The American Psychiatric Association is the main professional organization of psychiatrists and trainee psychiatrists in the United States, and the most influential world-wide....
     (APA) and the National Institute of Mental Health
    National Institute of Mental Health

    The National Institute of Mental Health is part of the federal government of the United States and the largest research organization in the world specializing in mental illness....
     (NIMH).


  • Finally, the blended model attempts to consider elements of all other models in developing a therapeutic approach to dependency. It holds that the mechanism of dependency is different for different individuals, and that each case must be considered on its own merits.


Neurobiological basis


The development of addiction is thought to involve a simultaneous process of 1) increased focus on and engagement in a particular behavior and 2) the attenuation or "shutting down" of other behaviors. For example, under certain experimental circumstances such as social deprivation
Deprivation

Deprivation may refer to:*Poverty*Sleep deprivation*Emotional Deprivation Disorder*Maternal deprivation...
 and boredom, animals allowed the unlimited ability to self-administer certain psychoactive drugs will show such a strong preference that they will forgo food, sleep, and sex for continued access. The neuro-anatomical correlate of this is that the brain regions involved in driving goal-directed behavior grow increasingly selective for particular motivating stimuli and rewards, to the point that the brain regions involved in the inhibition of behavior can no longer effectively send "stop" signals. A good analogy is to imagine flooring the gas pedal in a car with very bad brakes. In this case, the limbic system is thought to be the major "driving force" and the orbitofrontal cortex is the substrate of the top-down inhibition.

A specific portion of the limbic circuit known as the mesolimbic
Mesolimbic pathway

The mesolimbic pathway is one of the dopaminergic pathways in the brain. The pathway begins in the ventral tegmentum of the mesencephalon and connects to the limbic system via the nucleus accumbens, the amygdala, and the hippocampus as well as to the prefrontal cortex....
 dopaminergic system is hypothesized to play an important role in translation of motivation to motor behavior- and reward-related learning in particular. It is typically defined as the ventral tegmental area (VTA), the nucleus accumbens, and the bundle of dopamine
Dopamine

Dopamine is a neurotransmitter occurring in a wide variety of animals, including both vertebrates and invertebrates. In the human brain, this phenethylamine functions as a neurotransmitter, activating the five types of dopamine receptors ? D1, D2, D3, D4 and D5, and their variants....
-containing fibers that are connecting them. This system is commonly implicated in the seeking out and consumption of rewarding stimuli or events, such as sweet-tasting foods or sexual interaction. However, its importance to addiction research goes beyond its role in "natural" motivation: while the specific site or mechanism of action may differ, all known drugs of abuse have the common effect in that they elevate the level of dopamine in the nucleus accumbens. This may happen directly, such as through blockade of the dopamine re-uptake mechanism (see cocaine
Cocaine

Cocaine is a crystalline tropane alkaloid that is obtained from the leaves of the coca plant. The name comes from "coca" in addition to the alkaloid suffix -ine, forming cocaine....
). It may also happen indirectly, such as through stimulation of the dopamine-containing neurons of the VTA that synapse onto neurons in the accumbens (see opiates). The euphoric effects of drugs of abuse are thought to be a direct result of the acute increase in accumbal dopamine.

The human body has a natural tendency to maintain homeostasis
Homeostasis

Homeostasis is the property of a system, either open system or closed system, that regulates its internal environment and tends to maintain a stable, constant condition....
, and the central nervous system is no exception. Chronic elevation of dopamine will result in a decrease in the number of dopamine receptors
Transmembrane receptor

Transmembrane receptors are integral membrane proteins, which reside and operate typically within a cell's plasma membrane, but also in the biological membrane of some subcellular compartments and organelles....
 available in a process known as downregulation. The decreased number of receptors changes the permeability of the cell membrane located post-synaptically, such that the post-synaptic neuron is less excitable- i.e.: less able to respond to chemical signaling with an electrical impulse, or action potential
Action potential

An action potential is a self-regenerating wave of electrochemical activity that allows nerve cells to carry a signal over a distance. It is the primary electrical signal generated by nerve cells, and arises from changes in the permeability of the nerve cell's axonal Cell membranes to specific ions....
. It is hypothesized that this dulling of the responsiveness of the brain's reward pathways contributes to the inability to feel pleasure, known as anhedonia
Anhedonia

In psychology, anhedonia is an inability to experience pleasure from normally pleasurable life events such as eating, exercise, and social or sexual interaction....
, often observed in addicts. The increased requirement for dopamine to maintain the same electrical activity is the basis of both physiological tolerance
Physiological tolerance

In physiology, physiological tolerance or drug tolerance is commonly encountered in pharmacology, when a subject's reaction to a drug decreases so that larger doses are required to achieve the same effect....
 and withdrawal
Withdrawal

Withdrawal, also known as withdrawal/abstinence syndrome, refers to the characteristic signs and symptoms that appear when a drug that causes physical dependence is regularly used for a long time and then suddenly discontinued or decreased in dosage....
 associated with addiction.

Downregulation can be classically conditioned. If a behavior consistently occurs in the same environment or contingently with a particular cue, the brain will adjust to the presence of the conditioned cues by decreasing the number of available receptors in the absence of the behavior. It is thought that many drug overdoses are not the result of a user taking a higher dose than is typical, but rather that the user is administering the same dose in a new environment.

In cases of physical dependency on depressant
Depressant

Depressant is a chemical agent that diminishes the function or activity of a specific part of the body.The term is used in particular with regard to the central nervous system ....
s of the central nervous system
Central nervous system

The central nervous system is the part of the nervous system that functions to coordinate the activity of all parts of the bodies of multicellular organisms....
 such as opioids, barbiturate
Barbiturate

Barbiturates are medication that act as central nervous system depressants, and by virtue of this they produce a wide spectrum of effects, from mild sedation to anesthesia....
s, or alcohol, the absence of the substance can lead to symptoms of severe physical discomfort. Withdrawal from alcohol or sedatives such as barbiturates or benzodiazepines (valium-family) can result in seizures and even death. By contrast, withdrawal from opioids, which can be extremely uncomfortable, is rarely if ever life-threatening. In cases of dependence and withdrawal, the body has become so dependent on high concentrations of the particular chemical that it has stopped producing its own natural versions (endogenous ligands) and instead produces opposing chemicals. When the addictive substance is withdrawn, the effects of the opposing chemicals can become overwhelming. For example, chronic use of sedatives (alcohol, barbiturate
Barbiturate

Barbiturates are medication that act as central nervous system depressants, and by virtue of this they produce a wide spectrum of effects, from mild sedation to anesthesia....
s, or benzodiazepines) results in higher chronic levels of stimulating neurotransmitter
Neurotransmitter

Neurotransmitters are chemistry which relay, amplify and modulate signals between a neuron and another cell . Neurotransmitters are packaged into vesicles that cluster beneath the membrane on the presynaptic side of a synapse, and are released into the synaptic cleft, where they bind to receptors in the membrane on the postsynaptic side of...
s such as glutamate. Very high levels of glutamate kill nerve cells, a phenomenon called excitatory neurotoxicity.

Criticism


A strong form of criticism comes from Thomas Szasz
Thomas Szasz

Thomas Stephen Szasz is a psychiatrist and academic. He is Professor Emeritus of Psychiatry at the State University of New York Health Science Center in Syracuse, New York, New York....
, who denies that addiction is a psychiatric problem. In many of his works, he argues that addiction is a choice, and that a drug addict is one who simply prefers a socially taboo substance rather than, say, a low risk lifestyle. In
Our Right to Drugs, Szasz cites the biography of Malcolm X
Malcolm X

Malcolm X , also known as Hajji Malik El-Shabazz , was an African American Muslim minister, public speaker, and human rights activist. To his admirers, he was a courageous advocate for the rights of African Americans, a man who indicted white America in the harshest terms for its crimes against black Americans....
 to corroborate his economic views towards addiction: Malcolm claimed that quitting cigarettes was harder than shaking his heroin
Heroin

Heroin is a opioid synthesized from morphine, a derivative of the opium poppy. It is the 3,6-acetate ester of morphine . The white crystalline form is commonly the hydrochloride salt diacetylmorphine hydrochloride, however heroin Freebase may also appear as a white powder....
 addiction. Szasz postulates that humans always have a choice, and it is foolish to call someone an 'addict' just because they prefer a drug
Drug

A drug, broadly speaking, is any chemical substance that, when absorbed into the body of a living organism, alters normal bodily function....
 induced euphoria
Happiness

Happiness is a state of mind or feeling such as contentment, satisfaction, pleasure, or joy. A variety of Philosophy, Religion, Psychology and Biology approaches have been taken to defining happiness and identifying its sources....
 to a more popular and socially welcome lifestyle.

Szasz is not alone in questioning the standard view of addiction. Professor John Booth Davies at the University of Strathclyde
University of Strathclyde

The University of Strathclyde , is a university in Glasgow, Scotland. It takes its name from the historic Kingdom of Strathclyde, the name of which also served as a Strathclyde from 1975 to 1996....
 has argued in his book
The Myth of Addiction that 'people take drugs because they want to and because it makes sense for them to do so given the choices available' as opposed to the view that 'they are compelled to by the pharmacology of the drugs they take'. He uses an adaptation of attribution theory
Attribution theory

Attribution theory is a social psychology theory developed by Fritz Heider, Harold Kelley, Edward E. Jones, and Lee Ross.The theory is concerned with the ways in which people explain the behavior of others or themselves with something else....
 (what he calls the theory of functional attributions) to argue that the statement 'I am addicted to drugs' is functional, rather than veridical. Stanton Peele
Stanton Peele

Stanton Peele, Ph. D., J.D., is a licensed psychologist, Lawyer, practicing psychotherapist and the author of books and articles on the subject of alcoholism, addiction and addiction treatment....
 has put forward similar views.

Experimentally, Bruce K. Alexander used the classic experiment of Rat Park
Rat Park

Rat Park was a study into drug addiction conducted in the 1970s by Canadian psychologist Bruce K. Alexander at Simon Fraser University in British Columbia, Canada....
 to show that 'addicted' behaviour in rats only occurred when the rats had no other options. When other options and behavioural opportunities were put in place, the rats soon showed far more complex behaviours.

Casual addiction

The word
addiction is also sometimes used colloquially to refer to something for which a person has a passion, such as books
Bibliophilia

Bibliophilia is the love of books. Accordingly a bibliophile loves books, but especially "for qualities of format." A bookworm loves books for their content, or otherwise loves Reading in general....
, chocolate
Chocoholism

Chocoholism is a portmanteau of "chocolate" and "alcoholism," referring to an addiction to chocolate. Some claim to suffer from this "condition" and describe themselves as chocoholics....
, work
Workaholic

A workaholic, colloquially, is a person who is Addiction to work .The phrase does not always imply that the person actually enjoys their work, but rather simply feels compelled to do it....
, the web, running, postage stamp collecting, or eating.

See also


Further reading

  • Ornstein, C., (2005-11-14). . LA Times.


External links