Acetanisole
Encyclopedia
Acetanisole is an aromatic chemical compound
Chemical compound
A chemical compound is a pure chemical substance consisting of two or more different chemical elements that can be separated into simpler substances by chemical reactions. Chemical compounds have a unique and defined chemical structure; they consist of a fixed ratio of atoms that are held together...

 with an aroma described as butter, caramel, fruity, nutty, sweet, and vanilla. It is used as a cigarette additive, a fragrance,, and a flavoring in food
Food additive
Food additives are substances added to food to preserve flavor or enhance its taste and appearance.Some additives have been used for centuries; for example, preserving food by pickling , salting, as with bacon, preserving sweets or using sulfur dioxide as in some wines...

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Acetanisole is found naturally in castoreum
Castoreum
Castoreum is the exudate from the castor sacs of the mature North American Beaver Castor canadensis and the European Beaver Castor fiber. Within the zoological realm, castoreum is the yellowish secretion of the castor sac in combination with the beaver's urine, used during scent marking of territory...

, the glandular secretion of the beaver
Beaver
The beaver is a primarily nocturnal, large, semi-aquatic rodent. Castor includes two extant species, North American Beaver and Eurasian Beaver . Beavers are known for building dams, canals, and lodges . They are the second-largest rodent in the world...

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Acetanisole can be prepared synthetically
Organic synthesis
Organic synthesis is a special branch of chemical synthesis and is concerned with the construction of organic compounds via organic reactions. Organic molecules can often contain a higher level of complexity compared to purely inorganic compounds, so the synthesis of organic compounds has...

 by Friedel-Crafts acylation of anisole
Anisole
Anisole, or methoxybenzene, is the organic compound with the formula CH3OC6H5. It is a colorless liquid with a smell reminiscent of anise seed, and in fact many of its derivatives are found in natural and artificial fragrances...

 with acetyl chloride
Acetyl chloride
Acetyl chloride, CH3COCl, also known as ethanoyl chloride or acyl chloride, is an acid chloride derived from acetic acid. It belongs to the class of organic compounds called acyl halides. It is a colorless liquid. Acetyl chloride does not exist in nature, because contact with water would hydrolyze...

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