L02AA Estrogen

Estrogen

Estrogens , oestrogens , or œstrogens, are a group of compounds named for their importance in the estrous cycle of humans and other animals. They are the primary female sex hormones. Natural estrogens are steroid hormones, while some synthetic ones are non-steroidal...

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L02AA01 Diethylstilbestrol

Diethylstilbestrol

Diethylstilbestrol is a synthetic nonsteroidal estrogen that was first synthesized in 1938. Human exposure to DES occurred through diverse sources, such as dietary ingestion from supplemented cattle feed and medical treatment for certain conditions, including breast and prostate cancers...

L02AA02 Polyestradiol phosphate

Polyestradiol phosphate

Polyestradiol phosphate is an estrogen used as an antineoplastic agent....

L02AA03 Ethinylestradiol

Ethinylestradiol

Ethynylestradiol , also ethynyl estradiol , is a derivative of estradiol. Ethynyl estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills...

L02AA04 Fosfestrol

Fosfestrol

Fosfestrol is a synthetic estrogen used as an antineoplastic agent....

L02AB Progestogens

L02AB01 Megestrol

Megestrol

Megestrol is a progesterone derivative with antineoplastic properties used in the treatment of advanced carcinoma of the breast and endometrium. When given in relatively high doses, Megestrol can substantially increase appetite in most individuals, even those with advanced cancer...

L02AB02 Medroxyprogesterone

Medroxyprogesterone

Medroxyprogesterone is a pregnane that acts as a progestin. An acylated derivative, medroxyprogesterone 17-acetate is clinically used as a drug. Compared to MPA, MP is approximately 100 fold less potent as a progestin...

L02AB03 Gestonorone

Gestonorone

Gestonorone is a progestagen hormone....

L02AE Gonadotropin-releasing hormone

Gonadotropin-releasing hormone

Gonadotropin-releasing hormone , also known as Luteinizing-hormone-releasing hormone and luliberin, is a tropic peptide hormone responsible for the release of follicle-stimulating hormone and luteinizing hormone from the anterior pituitary. GnRH is synthesized and released from neurons within...

 analogues

L02AE01 Buserelin

Buserelin

Buserelin is a Gonadotropin-releasing hormone agonist . By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone and follicle stimulating hormone...

L02AE02 Leuprorelin

L02AE03 Goserelin

Goserelin

Goserelin acetate is an injectable gonadotropin releasing hormone superagonist , also known as a luteinizing hormone releasing hormone agonist. Structurally, it is a decapeptide...

L02AE04 Triptorelin

Triptorelin

Triptorelin, a decapeptide , is a gonadotropin-releasing hormone agonist used at the acetate or pamoate salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone and follicle stimulating hormone...

L02BA Anti-estrogens

L02BA01 Tamoxifen

Tamoxifen

Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, hence tamoxifen may be characterized as a mixed agonist/antagonist...

L02BA02 Toremifene

Toremifene

Toremifene citrate is an oral selective estrogen receptor modulator which helps oppose the actions of estrogen in the body. Licensed in the United States under the brand name Fareston, toremifene citrate is FDA-approved for use in advanced breast cancer...

L02BA03 Fulvestrant

Fulvestrant

Fulvestrant, also known as ICI 182,780, is a drug treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy. It is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and...

L02BB Anti-androgens

L02BB01 Flutamide

Flutamide

Flutamide is an oral nonsteroidal antiandrogen drug primarily used to treat prostate cancer. It competes with testosterone and its powerful metabolite, dihydrotestosterone for binding to androgen receptors in the prostate gland. By doing so, it prevents them from stimulating the prostate cancer...

L02BB02 Nilutamide

Nilutamide

Nilutamide is an antiandrogen medication used in the treatment of advanced stage prostate cancer. Nilutamide blocks the androgen receptor, preventing its interaction with testosterone. Because most prostate cancer cells rely on the stimulation of the androgen receptor for growth and survival,...

L02BB03 Bicalutamide

Bicalutamide

Bicalutamide is an oral non-steroidal anti-androgen used in the treatment of prostate cancer and hirsutism...

L02BG Enzyme inhibitors

L02BG01 Aminogluthetimide

L02BG02 Formestane

Formestane

Formestane belongs to a class of drugs known as 2 aromatase inhibitors. It is used in the treatment of estrogen-receptor positive breast cancer in post-menopausal women. It is available as an intramuscular depot injection ....

L02BG03 Anastrozole

Anastrozole

Anastrozole is an aromatase-inhibiting drug approved for treatment of breast cancer after surgery, as well as for metastasis in both pre and post-menopausal women. The severity of breast cancer is increased by estrogen, as sex hormones cause hyperplasia, and differentiation at estrogen receptor...

L02BG04 Letrozole

Letrozole

Letrozole is an oral non-steroidal aromatase inhibitor for the treatment of hormonally-responsive breast cancer after surgery.Estrogens are produced by the conversion of androgens through the activity of the aromatase enzyme...

L02BG05 Vorozole

Vorozole

Vorozole is an imidazole based competitive inhibitor of the aromatase enzyme. It underwent clinical testing for evaluation for use as an antineoplastic agent; however it was withdrawn from testing when no difference was detected in the duration of median survival as compared to the progestational...

L02BG06 Exemestane

Exemestane

Exemestane is a drug used to treat breast cancer. It is a member of the class of drugs known as aromatase inhibitors. Some breast cancers require estrogen to grow. Those cancers have estrogen receptors , and are called ER-positive. They may also be called estrogen-responsive,...

L02BX Other hormone antagonists and related agents

L02BX01 Abarelix

Abarelix

Abarelix is an injectable gonadotropin-releasing hormone antagonist . It is primarily used in oncology to reduce the amount of testosterone made in patients with advanced symptomatic prostate cancer for which no other treatment options are available...

L02BX02 Degarelix

Degarelix

Degarelix or degarelix acetate is a hormonal therapy used in the treatment of prostate cancer. During development it was known as FE200486....