8-Hydroxyguanosine
Encyclopedia
8-Hydroxyguanosine is a nucleoside
which is an oxidative derivative of guanosine
. Measurement of the levels of 8-hydroxyguanosine is used as a biomarker of oxidative stress
.
Nucleoside
Nucleosides are glycosylamines consisting of a nucleobase bound to a ribose or deoxyribose sugar via a beta-glycosidic linkage...
which is an oxidative derivative of guanosine
Guanosine
Guanosine is a purine nucleoside comprising guanine attached to a ribose ring via a β-N9-glycosidic bond. Guanosine can be phosphorylated to become guanosine monophosphate , cyclic guanosine monophosphate , guanosine diphosphate , and guanosine triphosphate...
. Measurement of the levels of 8-hydroxyguanosine is used as a biomarker of oxidative stress
Oxidative stress
Oxidative stress represents an imbalance between the production and manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage...
.