17-N-allylamino-17-demethoxygeldanamycin
Encyclopedia
17-N-Allylamino-17-demethoxygeldanamycin is a derivative of the antibiotic geldanamycin
that is being studied in the treatment of cancer
, specific young patients with certain types of leukemia
or solid tumors, especially kidney
tumors.
It works by targeting Hsp90
, which is expressed in those tumors. It acts as an HSP inhibitor.
It belongs to the family of drugs
called antitumor antibiotics.
Geldanamycin
Geldanamycin is a benzoquinone ansamycin antibiotic that binds to Hsp90 and inhibits its function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis.Geldanamycin induces the degradation of proteins...
that is being studied in the treatment of cancer
Cancer
Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...
, specific young patients with certain types of leukemia
Leukemia
Leukemia or leukaemia is a type of cancer of the blood or bone marrow characterized by an abnormal increase of immature white blood cells called "blasts". Leukemia is a broad term covering a spectrum of diseases...
or solid tumors, especially kidney
Kidney
The kidneys, organs with several functions, serve essential regulatory roles in most animals, including vertebrates and some invertebrates. They are essential in the urinary system and also serve homeostatic functions such as the regulation of electrolytes, maintenance of acid–base balance, and...
tumors.
It works by targeting Hsp90
Hsp90
Hsp90 is a molecular chaperone and is one of the most abundant proteins expressed in cells. It is a member of the heat shock protein family, which is upregulated in response to stress...
, which is expressed in those tumors. It acts as an HSP inhibitor.
It belongs to the family of drugs
Medication
A pharmaceutical drug, also referred to as medicine, medication or medicament, can be loosely defined as any chemical substance intended for use in the medical diagnosis, cure, treatment, or prevention of disease.- Classification :...
called antitumor antibiotics.