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Valeric acid

 

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Valeric acid



 
 
Valeric acid, or pentanoic acid, is a straight-chain alkyl
Alkyl

An alkyl is a univalent Radical consisting of carbon and hydrogen atoms, arranged in a chain. The Alkyls form homologous series with the general formula CnH2n+1....
 carboxylic acid
Carboxylic acid

Carboxylic acids are organic acids characterized by the presence of a carboxyl group, which has the Chemical formula -COH, usually written -COOH or -CO2H....
 with the chemical formula
Chemical formula

A chemical formula is a way of expressing information about the atoms that constitute a particular chemical compound, and how the relationship between those atoms changes in chemical reactions....
 C5H10O2. Like other low-molecular-weight carboxylic acids, it has a very unpleasant odor. It is found naturally in the perennial flowering plant valerian (Valeriana officinalis), from which it gets its name. Its primary use is in the synthesis of its ester
Ester

An ester is an often Aroma compound organic chemistry or partially organic compound formed by the reaction between an acid and an alcohol or aromatic alcohol with the elimination of water....
s. Volatile esters of valeric acid tend to have pleasant odors and are used in perfumes and cosmetics.






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Encyclopedia


Valeric acid, or pentanoic acid, is a straight-chain alkyl
Alkyl

An alkyl is a univalent Radical consisting of carbon and hydrogen atoms, arranged in a chain. The Alkyls form homologous series with the general formula CnH2n+1....
 carboxylic acid
Carboxylic acid

Carboxylic acids are organic acids characterized by the presence of a carboxyl group, which has the Chemical formula -COH, usually written -COOH or -CO2H....
 with the chemical formula
Chemical formula

A chemical formula is a way of expressing information about the atoms that constitute a particular chemical compound, and how the relationship between those atoms changes in chemical reactions....
 C5H10O2. Like other low-molecular-weight carboxylic acids, it has a very unpleasant odor. It is found naturally in the perennial flowering plant valerian (Valeriana officinalis), from which it gets its name. Its primary use is in the synthesis of its ester
Ester

An ester is an often Aroma compound organic chemistry or partially organic compound formed by the reaction between an acid and an alcohol or aromatic alcohol with the elimination of water....
s. Volatile esters of valeric acid tend to have pleasant odors and are used in perfumes and cosmetics. Ethyl valerate and pentyl valerate
Pentyl pentanoate

Pentyl pentanoate is an ester used in dilute solution to replicate the scent or flavour of apple, and sometimes pineapple. It is referred to as pentyl valerate or amyl pentanoate using classical nomenclature....
 are used as food additives because of their fruity flavors.

Valeric acid has a similar structure to both GHB
Gamma-Hydroxybutyric acid

gamma-Hydroxybutyric acid, 4-hydroxybutanoic acid, or GHB is a naturally-occurring substance found in the central nervous system, wine, beef, small citrus fruits, and almost all animals in small amounts....
 and the neurotransmitter GABA
Gamma-aminobutyric acid

γ-Aminobutyric acid is the chief inhibitory neurotransmitter in the mammalian central nervous system. It plays an important role in regulating neuronal excitability throughout the nervous system....
. It differs from valproic acid
Valproic acid

Valproic acid is a chemical compound that has found clinical use as an anticonvulsant and mood stabilizer medication, primarily in the treatment of epilepsy, bipolar disorder, and less commonly major depressive disorder....
 simply by lacking a 3-carbon side chain.

Safety

Valeric acid can cause irritation to humans if it comes into contact with the skin or eyes, but otherwise causes little harm because it tends not to vapourise at room temperature unless it is in its pure glacial form. It is, however, toxic to aquatic life and so should not be disposed of into drains without first diluting the acidic solution.

Applications

Valerian root has a long history of use as an herbal sedative/hypnotic.

Valeric acid, if applied directly, has been claimed to be an effective treatment for acne, as yet without support from peer reviewed trials. Derivates such as Diflucortolone valerate
Diflucortolone valerate

Diflucortolone valerate External links...
 are used as topical corticosteroids for dermatology
Dermatology

Dermatology is the branch of medicine dealing with the skin and Skin disease, a unique specialty with both medical and surgical aspects. The name of this specialty originated in the form of the words dermologie and, a little later, dermatologia ....
.

See also

  • Pivalic acid
    Pivalic acid

    Pivalic acid is a carboxylic acid with a molecular formula of C5H10O2....
     (2,2-dimethylpropanoic acid)