USS Natchez may refer to:
, a sloop-of-war launched in 1827.
, the name and designation of USS Oceanographer (AGS-3) from April to May 1942
, an Asheville-class patrol frigate, launched in 1942, served in World War II; sold to Dominican Republic in 1948 and served as Juan Pablo Duarte (F–102) until she sank in 1957.

See also:

• Natchez (boat)
  Natchez (boat)
  Natchez has been the name of several steamboats, and four naval vessels, each named after the city of Natchez, Mississippi or the Natchez people. The current one has been in operation since 1975. The previous Natchez were all operated in the nineteenth century, most by Captain Thomas P. Leathers...
  
  : Civilian boats named Natchez