Tombusvirus 5' UTR
Encyclopedia
Tombusvirus 5' UTR is an important cis-regulatory
region of the Tombus virus
genome.
Tomato bushy stunt virus is the prototype member of the Tombusviridae
family. The genome of this virus is positive sense single stranded RNA. Replication occurs via a negative strand RNA intermediate. In addition to viral proteins p33 and the RNA-dependent RNA polymerase p92, and unknown host factors, conserved and structural regions within the 5'untranslated region
(5'UTR) are important for regulating genome replication.
2 RNA domains in the 5' UTR have been reported, a 5' T-shaped domain (TSD) followed by a stem-loop (SL5) and a downstream domain (DSD). TSD-DSD interactions are proposed to be involved in the mediation of viral RNA replication.
An interesting feature of Tombusvirus is its ability to support the replication of defective interfering (DI) RNAs. These sub-viral replicons are small, non-coding, deletion mutants of the viral genome that maintain cis-acting RNA elements necessary for replication
Other non-coding RNA
structures in Tombusvirus include the 3' UTR region IV
and an internal replcation element
.
Cis-regulatory element
A cis-regulatory element or cis-element is a region of DNA or RNA that regulates the expression of genes located on that same molecule of DNA . This term is constructed from the Latin word cis, which means "on the same side as". These cis-regulatory elements are often binding sites for one or...
region of the Tombus virus
Tombusvirus
The genus Tombusvirus are part of the family Tombusviridae and are members of group IV of the Baltimore classification of viruses. The genomes consist of positive sense single-stranded RNA with a genome size of 4800 nucleotides. The virions are non-enveloped with a diameter of 30 nm and have...
genome.
Tomato bushy stunt virus is the prototype member of the Tombusviridae
Tombusviridae
Tombusviridae is a family of single-stranded positive sense RNA plant viruses. The name is derived from the type species of the Tombusvirus genus, Tomato bushy stunt virus...
family. The genome of this virus is positive sense single stranded RNA. Replication occurs via a negative strand RNA intermediate. In addition to viral proteins p33 and the RNA-dependent RNA polymerase p92, and unknown host factors, conserved and structural regions within the 5'untranslated region
Five prime untranslated region
A messenger ribonucleic acid molecule codes for a protein through translation. The mRNA also contains regions that are not translated: in eukaryotes these include the 5' untranslated region, 3' untranslated region, 5' cap and poly-A tail....
(5'UTR) are important for regulating genome replication.
2 RNA domains in the 5' UTR have been reported, a 5' T-shaped domain (TSD) followed by a stem-loop (SL5) and a downstream domain (DSD). TSD-DSD interactions are proposed to be involved in the mediation of viral RNA replication.
An interesting feature of Tombusvirus is its ability to support the replication of defective interfering (DI) RNAs. These sub-viral replicons are small, non-coding, deletion mutants of the viral genome that maintain cis-acting RNA elements necessary for replication
Other non-coding RNA
Non-coding RNA
A non-coding RNA is a functional RNA molecule that is not translated into a protein. Less-frequently used synonyms are non-protein-coding RNA , non-messenger RNA and functional RNA . The term small RNA is often used for short bacterial ncRNAs...
structures in Tombusvirus include the 3' UTR region IV
Tombusvirus 3' UTR region IV
Tombusvirus 3' UTR is an important cis-regulatory region of the Tombus virus genome.Tomato bushy stunt virus is the prototype member of the Tombusviridae family. The genome of this virus is positive sense single stranded RNA. Replication occurs via a negative strand RNA intermediate...
and an internal replcation element
Tombusvirus internal replication element (IRE)
In virology, the tombusvirus internal replication element is a segment of RNA located within the region coding for p92 polymerase. This element is essential for viral replication; specifically, it is thought to be required at an early stage of replication, such as template recruitment and/or...
.