Tombus virus defective interfering (DI) RNA region 3

Tombus virus defective interfering (DI) RNA region 3 is an important cis-regulatory

Cis-regulatory element

A cis-regulatory element or cis-element is a region of DNA or RNA that regulates the expression of genes located on that same molecule of DNA . This term is constructed from the Latin word cis, which means "on the same side as". These cis-regulatory elements are often binding sites for one or...

region identified in the 3' UTR of Tombusvirus
Tombusvirus
The genus Tombusvirus are part of the family Tombusviridae and are members of group IV of the Baltimore classification of viruses. The genomes consist of positive sense single-stranded RNA with a genome size of 4800 nucleotides. The virions are non-enveloped with a diameter of 30 nm and have...

defective interfering particles (DI).

Defective interfering RNAs are small sub-viral replicon

Replicon

*A Replicon in genetics is a region of DNA or RNA, that replicates from a single origin of replication.*Replicon is a software company providing timesheet and expense management software....

s which are non-coding deletion mutants of the virus that maintain cis-acting RNA elements necessary for replication

Replication

Replication may refer to:Science* Replication is one of the main principles of the scientific method, a.k.a. reproducibility** Replication , the repetition of a test or complete experiment...

of the host virus. This conserved region of the 3'UTR has been found to enhance DI RNA accumulation by approximately 10-fold as well as mediating viral replication

Viral replication

Viral replication is the term used by virologists to describe the formation of biological viruses during the infection process in the target host cells. Viruses must first get into the cell before viral replication can occur. From the perspective of the virus, the purpose of viral replication is...

See also