Transient receptor potential cation channel, subfamily C, member 4, also known as TRPC4, is a human gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

 encoding a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 of the same name.
TRPC4 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with TRPC1

TRPC1

Transient receptor potential channel 1 is a protein that in humans is encoded by the TRPC1 gene.- Function :TRPC1 is an ion channel located on the plasma membrane of numerous human and animal cell types. It is a nonspecific cation channel, which means that both sodium and calcium ions can pass...

, ITPR1

ITPR1

Inositol 1,4,5-trisphosphate receptor type 1 is a protein that in humans is encoded by the ITPR1 gene.-Interactions:ITPR1 has been shown to interact with CA8, PRKG1, FKBP1A, MRVI1, RHOA, AHCYL1, EPB41L1 and TRPC4.-External Links:*...

 and TRPC5

TRPC5

Short transient receptor potential channel 5 also known as transient receptor protein 5 is a protein that in humans is encoded by the TRPC5 gene. TrpC5 is subtype of the TRPC family of mammalian transient receptor potential ion channels.- Function :TrpC5 is one of the seven mammalian TRPC proteins...

.
A 2011 study showed that deletion of the trpc4 gene in rats decreased levels of sociability in a social exploration task. These results suggest that TRPC4 may play a role in regulating social anxiety in a number of different disorders .
The nonselective cation channel TRPC4 has been shown to be present in high abundance in the corticolimbic regions of the brain.