TOX2
Encyclopedia
TOX high mobility group box family member 2, also known as TOX2, is a human gene
.
The protein
encoded by this gene is a member of a subfamily of transcription factor
s that also includes TOX
, TOX3
, and TOX4
that share almost identical HMG-box
DNA-binding domain
s which function to modify chromatin
structure.
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
The protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
encoded by this gene is a member of a subfamily of transcription factor
Transcription factor
In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...
s that also includes TOX
TOX
Thymocyte selection-associated high mobility group box protein TOX is a protein that in humans is encoded by the TOX gene.-Structure and function:...
, TOX3
TOX3
TOX high mobility group box family member 3, also known as TOX3, is a human gene.The protein encoded by this gene is a member of a subfamily of transcription factors that also includes TOX, TOX2, and TOX4 that share almost identical HMG-box DNA-binding domains which function to modify chromatin...
, and TOX4
TOX4
TOX4 also known as KIAA0737, is a human gene.-Further reading:...
that share almost identical HMG-box
HMG-box
The HMG-box is a protein domain which is involved in DNA binding.-Structure:The structure of the HMG-box domain contains three alpha helices separated by loops .-Function:...
DNA-binding domain
DNA-binding domain
A DNA-binding domain is an independently folded protein domain that contains at least one motif that recognizes double- or single-stranded DNA. A DBD can recognize a specific DNA sequence or have a general affinity to DNA...
s which function to modify chromatin
Chromatin
Chromatin is the combination of DNA and proteins that make up the contents of the nucleus of a cell. The primary functions of chromatin are; to package DNA into a smaller volume to fit in the cell, to strengthen the DNA to allow mitosis and meiosis and prevent DNA damage, and to control gene...
structure.