Synthesizing Unit
Encyclopedia
Synthesizing Units are generalized enzymes that follow the rules of classic enzyme kinetics
with two modifications:
The first modification is an extension of the classic theory; if arrival fluxes are taken proportional to substrate concentrations, the classic theory results. This extension allows application in spatially heterogeneous environments (such as in living cells), and to treat photons and molecules in the same framework (important in photosynthesis).
The second modification allows a substantial simplification of the classic theory, and so application in complex metabolic networks.
Theory on Synthesizing Units is used in Dynamic Energy Budget
theory, where 4 basic modes are distinguished:
Mixtures of the 4 basic modes can occur, especially if the substrates represent generalized compounds, rather than pure chemical compounds. A generalized compound is a mixture of chemical compounds that does not change in composition.
Enzyme kinetics
Enzyme kinetics is the study of the chemical reactions that are catalysed by enzymes. In enzyme kinetics, the reaction rate is measured and the effects of varying the conditions of the reaction investigated...
with two modifications:
- product formation is not taken to be a function of substrate concentrations but of substrate fluxes that arrive at the SUs
- the dissociation rate of the substrate-SU complex to (unchanged) substrate and (unbounded) SU is assumed to be small.
The first modification is an extension of the classic theory; if arrival fluxes are taken proportional to substrate concentrations, the classic theory results. This extension allows application in spatially heterogeneous environments (such as in living cells), and to treat photons and molecules in the same framework (important in photosynthesis).
The second modification allows a substantial simplification of the classic theory, and so application in complex metabolic networks.
Theory on Synthesizing Units is used in Dynamic Energy Budget
Dynamic energy budget
The Dynamic Energy Budget theory aims to identify simple quantitative rules for the organization of metabolism of individual organisms that can be understood from basic first principles...
theory, where 4 basic modes are distinguished:
- the substrates can be substitutable or supplementary (= complementary); if the transformations A -> C and B -> C can occur, substrates A and B are said to be substitutable with respect to their transformation to C, if both are required to produce C they are said to be supplementary
- the processing of these substrates by SUs can be sequential or parallel; if in the transformation A + B -> C the binding of substrate A to the SU does not affect that of B, these substrates are processed simultaneously, if not these substrates are processed sequentially
Mixtures of the 4 basic modes can occur, especially if the substrates represent generalized compounds, rather than pure chemical compounds. A generalized compound is a mixture of chemical compounds that does not change in composition.