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Submitochondrial particle

 

 
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Submitochondrial particle
 
 
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A submitochondrial particle is a compartmentalized membranous product of exposing mitochondria to ultrasound. This causes the cristae to pinch off forcing the inner mitochondrial membrane inside out. As a consequence, the F1 particle
ATP synthase

An ATP synthase is a general term for an enzyme that can synthesize adenosine triphosphate from adenosine diphosphate and inorganic phosphate by using some form of energy....
 becomes exposed and on the outside. Using chaotropic agent
Chaotropic agent

A chaotropic agent, also known as chaotropic reagent and chaotrope, is a substance which disrupts the three dimensional structure in macromolecules such as proteins, DNA, or RNA and denaturation them....
s such as urea
Urea

Urea is an organic compound with the chemical formula 2carbonoxygen.Urea is also known by the International Nonproprietary Name carbamide, as established by the World Health Organization....
, these particles can be removed, dissociating the related ATPase activity from the membrane. However, the electron transport complexes remain on the membrane.

If F1 particles are removed from submitochondrial particles, they can be reconstituted by carefully removing the chaotropic agent.






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A submitochondrial particle is a compartmentalized membranous product of exposing mitochondria to ultrasound. This causes the cristae to pinch off forcing the inner mitochondrial membrane inside out. As a consequence, the F1 particle
ATP synthase

An ATP synthase is a general term for an enzyme that can synthesize adenosine triphosphate from adenosine diphosphate and inorganic phosphate by using some form of energy....
 becomes exposed and on the outside. Using chaotropic agent
Chaotropic agent

A chaotropic agent, also known as chaotropic reagent and chaotrope, is a substance which disrupts the three dimensional structure in macromolecules such as proteins, DNA, or RNA and denaturation them....
s such as urea
Urea

Urea is an organic compound with the chemical formula 2carbonoxygen.Urea is also known by the International Nonproprietary Name carbamide, as established by the World Health Organization....
, these particles can be removed, dissociating the related ATPase activity from the membrane. However, the electron transport complexes remain on the membrane.

If F1 particles are removed from submitochondrial particles, they can be reconstituted by carefully removing the chaotropic agent.