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Stem cell factor (SCF), otherwise known as KIT ligand or Steel factor,is a cytokine
Cytokine

Cytokines are a category of signaling molecules that, like hormones and neurotransmitters, are used extensively in cell communication. They are proteins, peptides or glycoproteins....
 which binds CD117
CD117

CD117, also called KIT or C-kit receptor, is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types....
 (c-Kit). SCF is also known as "steel factor" or "c-kit ligand". SCF exists in two forms, cell surface bound SCF and soluble (or free) SCF. Soluble SCF is produced by the cleavage of surface bound SCF by metalloproteases.

SCF is a growth factor important for the survival, proliferation, and differentiation of hematopoietic stem cells and other hematopoietic progenitor cells.






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Encyclopedia


Stem cell factor (SCF), otherwise known as KIT ligand or Steel factor,is a cytokine
Cytokine

Cytokines are a category of signaling molecules that, like hormones and neurotransmitters, are used extensively in cell communication. They are proteins, peptides or glycoproteins....
 which binds CD117
CD117

CD117, also called KIT or C-kit receptor, is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types....
 (c-Kit). SCF is also known as "steel factor" or "c-kit ligand". SCF exists in two forms, cell surface bound SCF and soluble (or free) SCF. Soluble SCF is produced by the cleavage of surface bound SCF by metalloproteases.

SCF is a growth factor important for the survival, proliferation, and differentiation of hematopoietic stem cells and other hematopoietic progenitor cells. One of its roles is to change the BFU-E(burst-forming unit-erythroid) cells, which are the earliest erythrocyte precursors in the erythrocytic series, into the CFU-E (colony-forming unit-erythroid) . SCF, along with bFGF (basic fibroblast growth factor
Fibroblast growth factor

Fibroblast growth factors, or FGFs, are a family of growth factors involved in angiogenesis, wound healing, and embryonic development. The FGFs are heparin-binding proteins and interactions with cell-surface associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction....
) and LIF
LIF

LIF, LiF or Lif may stand for:* Leukemia inhibitory factor, a chemical in cells that affects their growth and development.* Laser-induced fluorescence, a spectroscopic method....
 (leukemia inhibitory factor), prevents spontaneous differentiation
Differentiation

Differentiation can mean the following:* The act of finding the derivative in mathematics* Differentiated instruction in education,* Cellular differentiation in biology...
 of primitive embryonic stem cell
Embryonic stem cell

Embryonic stem cells are stem cells derived from the inner cell mass of an early stage embryo known as a blastocyst. Human embryos reach the blastocyst stage 4?5 days post Human fertilization, at which time they consist of 50?150 cells....
s in cell culture.

Ancestim
Ancestim

Ancestim is a recombinant methionyl human stem cell factor, commonly known by the name StemGen.It is a 166 amino acid protein produced by Ecoli bacteria into which a gene has been inserted for soluble human stem cell factor....
 is a recombinant form of SCF.

Further reading


External links

  • - KEGG pathway: Hematopoietic cell lineage