Spi-1 (PU.1) 5' UTR regulatory element
Encyclopedia
The Spi-1 5' UTR regulatory element is an RNA element
found in the 5' UTR of Spi-1 mRNA which is able to inhibit the translation
Spi-1 transcripts by 8-fold. Spi-1 regulates myeloid gene expression during haemopoietic
development. Mutations in this regulatory region of the 5' UTR can lead to overexpression of Spi-1 which has been linked to development of leukaemia.
Cis-regulatory element
A cis-regulatory element or cis-element is a region of DNA or RNA that regulates the expression of genes located on that same molecule of DNA . This term is constructed from the Latin word cis, which means "on the same side as". These cis-regulatory elements are often binding sites for one or...
found in the 5' UTR of Spi-1 mRNA which is able to inhibit the translation
Translation
Translation is the communication of the meaning of a source-language text by means of an equivalent target-language text. Whereas interpreting undoubtedly antedates writing, translation began only after the appearance of written literature; there exist partial translations of the Sumerian Epic of...
Spi-1 transcripts by 8-fold. Spi-1 regulates myeloid gene expression during haemopoietic
Haematopoiesis
Haematopoiesis is the formation of blood cellular components. All cellular blood components are derived from haematopoietic stem cells...
development. Mutations in this regulatory region of the 5' UTR can lead to overexpression of Spi-1 which has been linked to development of leukaemia.