Sialyl lewis a
Encyclopedia
Sialyl LewisA, also known as sialyl LeA and SLeA, is a tetrasaccharide carbohydrate
that is usually attached to O-glycans
on the surface of cells. It is known to play a vital role in cell-to-cell recognition processes.
Occurrence of the Sialyl Lewis A antigen, detected with the CA19-9
antibody, is highly correlated advanced epithelial cancers, such as stage III and stage IV colorectal cancers.
Carbohydrate
A carbohydrate is an organic compound with the empirical formula ; that is, consists only of carbon, hydrogen, and oxygen, with a hydrogen:oxygen atom ratio of 2:1 . However, there are exceptions to this. One common example would be deoxyribose, a component of DNA, which has the empirical...
that is usually attached to O-glycans
Glycans
The term glycan refers to a polysaccharide or oligosaccharide. Glycans usually consist solely of O-glycosidic linkages of monosaccharides. For example, cellulose is a glycan composed of beta-1,4-linked D-glucose, and chitin is a glycan composed of beta-1,4-linked N-acetyl-D-glucosamine...
on the surface of cells. It is known to play a vital role in cell-to-cell recognition processes.
Occurrence of the Sialyl Lewis A antigen, detected with the CA19-9
CA19-9
CA19-9 is a tumor marker that is used primarily in the management of pancreatic cancer.-History:...
antibody, is highly correlated advanced epithelial cancers, such as stage III and stage IV colorectal cancers.