Sequestosome 1
Encyclopedia
Sequestosome-1 is a protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the SQSTM1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.

Interactions

Sequestosome 1 has been shown to interact
Protein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with RAD23A
RAD23A
UV excision repair protein RAD23 homolog A is a protein that in humans is encoded by the RAD23A gene.-Interactions:RAD23A has been shown to interact with PSMD4, Sequestosome 1 and Ataxin 3.-Further reading:...

, TrkA
TrkA
High affinity nerve growth factor receptor also known as neurotrophic tyrosine kinase receptor type 1 or TRK1-transforming tyrosine kinase protein or Trk-A is a protein that in humans is encoded by the NTRK1 gene....

, TrkB
TrkB
TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the NTRK2 gene.-Function:...

, PRKCI
PRKCI
Protein kinase C iota type is an enzyme that in humans is encoded by the PRKCI gene.-Interactions:PRKCI has been shown to interact with Glyceraldehyde 3-phosphate dehydrogenase, Centaurin, alpha 1, Phosphoinositide-dependent kinase-1, FRS2, SMG1 , Sequestosome 1 and PARD3.-Further reading:...

, RIPK1
RIPK1
Receptor-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the RIPK1 gene.-Interactions:RIPK1 has been shown to interact with CA11, RIPK3, RNF11, Baculoviral IAP repeat-containing protein 3, CFLAR, BIRC2, Caspase 8, RNF216, TNFRSF1A, Sequestosome 1, TRAF2,...

, TRAF6
TRAF6
TRAF6 is a TRAF human protein.-Interactions:TRAF6 has been shown to interact with SDCBP, IRAK2, IRAK1, MAP3K7IP2, MAP3K7IP1, TNFRSF13B, FHL2, CD40, IKBKG, RANK, HSPB2, UBE2N, SIGIRR, TAX1BP1, ASK1, PPP4C, TNFAIP3, Sequestosome 1, MAP3K7 and Ubiquitin C....

 and MAP1LC3A
MAP1LC3A
Microtubule-associated proteins 1A/1B light chain 3A is a protein that in humans is encoded by the MAP1LC3A gene.. MAPLC3A is the mammalian homologue of yeast ATG8, an important marker and effector of autophagy.-Interactions:...

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Further reading

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