Scoulerine
Encyclopedia
Scoulerine, also known as discretamine and aequaline, is an alkaloid
Alkaloid
Alkaloids are a group of naturally occurring chemical compounds that contain mostly basic nitrogen atoms. This group also includes some related compounds with neutral and even weakly acidic properties. Also some synthetic compounds of similar structure are attributed to alkaloids...

 found in the Opium poppy
Opium poppy
Opium poppy, Papaver somniferum, is the species of plant from which opium and poppy seeds are extracted. Opium is the source of many opiates, including morphine , thebaine, codeine, papaverine, and noscapine...

, Croton flavens
Croton (genus)
Croton is an extensive flowering plant genus in the spurge family, Euphorbiaceae, established by Carl Linnaeus in 1737. The plants of this genus were described and introduced to Europeans by Georg Eberhard Rumphius. The common names for this genus are rushfoil and croton, but the latter also...

, and certain plants in the Erythrina
Erythrina
Erythrina is a genus of flowering plants in the pea family, Fabaceae. It contains about 130 species, which are distributed in tropical and subtropical regions worldwide. They are trees, growing up to in height...

 genus. Studies show that scoulerine is an antagonist
Antagonist
An antagonist is a character, group of characters, or institution, that represents the opposition against which the protagonist must contend...

 at the α2-adrenoceptor, α1D-adrenoceptor and 5-HT receptor
5-HT receptor
The serotonin receptors, also known as 5-hydroxytryptamine receptors or 5-HT receptors, are a group of G protein-coupled receptors and ligand-gated ion channels found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neurotransmission...

. It has also been found to be a GABAA receptor agonist.
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