SX-3228
Encyclopedia
SX-3228 is a sedative
and hypnotic
drug used in scientific research. It has similar effects to sedative-hypnotic benzodiazepine
drugs, but is structurally distinct and so is classed as a nonbenzodiazepine
hypnotic.
SX-3228 is a subtype-selective GABAA
agonist acting primarily at the α1 subtype. It thus has similar effects to other α1-selective drugs such as zolpidem
and zaleplon
in animal studies. It only partly substitutes for ethanol, and is a strong sedative-hypnotic with only limited anxiolytic
effects which appear only at doses that also produce significant sedation.
Sedative
A sedative or tranquilizer is a substance that induces sedation by reducing irritability or excitement....
and hypnotic
Hypnotic
Hypnotic drugs are a class of psychoactives whose primary function is to induce sleep and to be used in the treatment of insomnia and in surgical anesthesia...
drug used in scientific research. It has similar effects to sedative-hypnotic benzodiazepine
Benzodiazepine
A benzodiazepine is a psychoactive drug whose core chemical structure is the fusion of a benzene ring and a diazepine ring...
drugs, but is structurally distinct and so is classed as a nonbenzodiazepine
Nonbenzodiazepine
The nonbenzodiazepines, also called benzodiazepine-like drugs, are a class of psychoactive drugs pharmacologically resembling the benzodiazepines, with similar benefits, side effects and risks, despite having dissimilar or entirely different chemical structures.-Classes:There are currently three...
hypnotic.
SX-3228 is a subtype-selective GABAA
GABA A receptor
The GABAA receptor is an ionotropic receptor and ligand-gated ion channel. Its endogenous ligand is γ-aminobutyric acid , the major inhibitory neurotransmitter in the central nervous system. Upon activation, the GABAA receptor selectively conducts Cl- through its pore, resulting in...
agonist acting primarily at the α1 subtype. It thus has similar effects to other α1-selective drugs such as zolpidem
Zolpidem
Zolpidem is a prescription medication used for the short-term treatment of insomnia, as well as some brain disorders. It is a short-acting nonbenzodiazepine hypnotic of the imidazopyridine class that potentiates gamma-aminobutyric acid , an inhibitory neurotransmitter, by binding to GABAA...
and zaleplon
Zaleplon
Zaleplon is a sedative/hypnotic, mainly used for insomnia. It is a nonbenzodiazepine hypnotic from the pyrazolopyrimidine class. In terms of adverse effects zaleplon appears to offer little improvement compared to both benzodiazepines and other non-benzodiazepine Z-drugs.Sonata is manufactured by...
in animal studies. It only partly substitutes for ethanol, and is a strong sedative-hypnotic with only limited anxiolytic
Anxiolytic
An anxiolytic is a drug used for the treatment of anxiety, and its related psychological and physical symptoms...
effects which appear only at doses that also produce significant sedation.