SNX6
Encyclopedia
Sorting Nexin 6 also known as SNX6 is a well-conserved membrane
-associated protein
belonging to the sorting nexin family that is a component of the retromer complex
. The protein contains a coiled-coil domain at its C terminus and a PX domain
at its N terminus. Binding to PIM1
causes translocation to the nucleus. SNX6 has been shown to associate with TRAF4
.
Biological membrane
A biological membrane or biomembrane is an enclosing or separatingmembrane that acts as a selective barrier, within or around a cell. It consists of a lipid bilayer with embedded proteins that may constitute close to 50% of membrane content...
-associated protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
belonging to the sorting nexin family that is a component of the retromer complex
Retromer
The retromer is a complex of proteins that has been shown to be important in recycling transmembrane receptors from endosomes to the trans-Golgi network .-Discovery:...
. The protein contains a coiled-coil domain at its C terminus and a PX domain
PX domain
The PX domain is a phosphoinositide-binding structural domain involved in targeting of proteins to cell membranes.This domain was first found in P40phox and p47phox domains of NADPH oxidase...
at its N terminus. Binding to PIM1
PIM1
Proto-oncogene serine/threonine-protein kinase Pim-1 is an enzyme that in humans is encoded by the PIM1 gene.Pim-1 is a proto-oncogene which encodes for the serine/threonine kinase of the same name. The pim-1 oncogene was first described in relation to murine T-cell lymphomas, as it was the locus...
causes translocation to the nucleus. SNX6 has been shown to associate with TRAF4
TRAF4
TNF receptor-associated factor 4 also known as RING finger protein 83 is a protein that in humans is encoded by the TRAF4 gene.TRAF4 is a member of the TNF receptor associated factor family, a family of scaffold proteins...
.