RTI-177
Overview
 
RTI-177 is a synthetic stimulant
Stimulant
Stimulants are psychoactive drugs which induce temporary improvements in either mental or physical function or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion, among others...

 drug from the phenyltropane
Phenyltropane
Phenyltropanes were originally developed to reduce cocaine addiction and dependency. In general these compounds act as inhibitors of the plasmalemmal monoamine reuptake transporters. Although RTI holds a strong position in this field, they are not the only researchers that have prepared these...

 family, which acts as a DRI
Dopamine reuptake inhibitor
A dopamine reuptake inhibitor is a type of drug that acts as a reuptake inhibitor for the neurotransmitter dopamine by blocking the action of the dopamine transporter...

 with micromolar affinity for the SERT
Serotonin transporter
The serotonin transporter is a monoamine transporter protein.This protein is an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it...

. RTI-177 has an unusually long duration of action of 20 hours or more, substantially longer than the related compound RTI-336 from which it differs in molecular structure only by the absence of a p-methyl group.

"the nonselective monoamine transporter
Monoamine transporter
Monoamine transporters are protein structures that function as integral plasma membrane transporters to regulate concentrations of extracellular monoamine neurotransmitters. Three major classes of MATs are responsible for the reuptake of their associated amine neurotransmitters...

 inhibitor RTI-126 and the DAT
Dopamine transporter
The dopamine transporter is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synapse back into cytosol, from which other transporters sequester DA and NE into vesicles for later storage and release...

-selective inhibitors RTI-150 and RTI-336 both had a faster rate of onset (30 min) and a short duration of action (4h).
Quotations

You know the day destroys the night, Night divides the day, Tried to run — Tried to hide — Break on through to the other side!

"Break Through (To The Other Side)" from The Doors (album)|The Doors (1967)

We chased our pleasures here, Dug our treasures there, But can you still recall The time we cried? Break on through to the other side.

"Break on Through (To The Other Side)" from The Doors

It hurts to set you free, but you’ll never follow me.

"The End" from The Doors (1967)

People are strange when you're a stranger Faces look ugly when you're alone Women seem wicked when you're unwanted Streets are uneven when you're down.

"People Are Strange" on the album Strange Days|Strange Days (1967)

When you're strange Faces come out of the rain When you're strange No one remembers your name When you're strange.

"People Are Strange" on the album Strange Days (1967)

Five to one, baby One in five No one here gets out alive, now You get yours, baby I'll get mine Gonna make it, baby If we try.

"Five to One" on the album Waiting for the Sun|Waiting for the Sun (1968)

The old get older And the young get stronger May take a week And it may take longer They got the guns But we got the numbers Gonna win, yeah We're takin' over Come on!

"Five to One" on the album Waiting for the Sun (1968)

At first flash of Eden, We race down to the sea. Standing there on Freedom's shore. Waiting for the sun...

"Waiting for the Sun" on the album Morrison Hotel|Morrison Hotel (1970)

This is the strangest life I’ve ever known.

"Waiting for the Sun" on the album Morrison Hotel (1970)

Killer on the roadHis brain is squirming like a toad.

"Riders on the Storm" from the album L.A. Woman|L.A. Woman (1971).

 
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