Pulmonary surfactant-associated protein B
Encyclopedia
Pulmonary surfactant-associated protein B is a protein
that in humans is encoded by the SFTPB gene
.
Pulmonary surfactant-associated protein B is a membrane protein
which manufactures surfactant
.
.
It is associated with Surfactant metabolism dysfunction
type 1.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the SFTPB gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Pulmonary surfactant-associated protein B is a membrane protein
Membrane protein
A membrane protein is a protein molecule that is attached to, or associated with the membrane of a cell or an organelle. More than half of all proteins interact with membranes.-Function:...
which manufactures surfactant
Surfactant
Surfactants are compounds that lower the surface tension of a liquid, the interfacial tension between two liquids, or that between a liquid and a solid...
.
Clinical significance
Humans and animals born with a congenital absence of SP-B suffer from intractable respiratory failureRespiratory failure
The term respiratory failure, in medicine, is used to describe inadequate gas exchange by the respiratory system, with the result that arterial oxygen and/or carbon dioxide levels cannot be maintained within their normal ranges. A drop in blood oxygenation is known as hypoxemia; a rise in arterial...
.
It is associated with Surfactant metabolism dysfunction
Surfactant metabolism dysfunction
Surfactant metabolism dysfunction is a condition where pulmonary surfactant is insufficient for adequate respiration.Types include:...
type 1.