Pseudomorphine
Encyclopedia
Pseudomorphine is a natural dimerisation product of the morphine
molecule in tandem and thus a common impurity in morphine concentrations. It was first described by Pelletier in 1835.
This compound may be synthesized by the oxidative coupling of morphine
by potassium ferricyanide
.
Morphine
Morphine is a potent opiate analgesic medication and is considered to be the prototypical opioid. It was first isolated in 1804 by Friedrich Sertürner, first distributed by same in 1817, and first commercially sold by Merck in 1827, which at the time was a single small chemists' shop. It was more...
molecule in tandem and thus a common impurity in morphine concentrations. It was first described by Pelletier in 1835.
This compound may be synthesized by the oxidative coupling of morphine
Morphine
Morphine is a potent opiate analgesic medication and is considered to be the prototypical opioid. It was first isolated in 1804 by Friedrich Sertürner, first distributed by same in 1817, and first commercially sold by Merck in 1827, which at the time was a single small chemists' shop. It was more...
by potassium ferricyanide
Potassium ferricyanide
Potassium ferricyanide is the chemical compound with the formula K3[Fe6]. This bright red salt contains the octahedrally coordinated [Fe6]3− ion. It is soluble in water and its solution shows some green-yellow fluorescence.-Preparation:...
.
See also
- Paramorphine (Thebaine)ThebaineThebaine , its name coming from the Greek Θῆβαι, Thēbai, an ancient city in Upper Egypt, is an opiate alkaloid. A minor constituent of opium, thebaine is chemically similar to both morphine and codeine, but has stimulatory rather than depressant effects, causing convulsions similar to strychnine...
- Morphine-N-oxideMorphine-N-oxideMorphine-N-oxide is an active opioid metabolite of morphine. Morphine itself, in trials with rats, acts 11–22 times more potent than morphine-N-oxide subcutaneously and 39–89 times more potent intraperitoneally...
- Morphine-3-glucuronideMorphine-3-glucuronideMorphine-3-glucuronide is a metabolite of morphine produced by UGT2B7. It is not active as an opioid agonist, but does have some action as a convulsant, which does not appear to be mediated through opioid receptors; it is mediated by GABA/glycinergic system...
- Morphine-6-glucuronideMorphine-6-glucuronideMorphine-6-glucuronide is a major active metabolite of morphine, and as such is the molecule responsible for much of the pain-relieving effects of morphine . M6G is formed from morphine by the enzyme UDP-Glucuronosyltransferase-2B7...