Pestivirus internal ribosome entry site (IRES)
Encyclopedia
This family represents the internal ribosome entry site
(IRES) of the pestivirus
es. The pestivirus IRES allows cap and end-independent translation of mRNA in the host cell. The IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre-initiation complex directly to the initiation codon and eliminates the requirement for the eukaryotic initiation factor
, eIF4F. The classical swine fever virus UTR describedappears to be longer at the 5' end than other pestivirus UTRs. This family represents the conserved core.
Internal ribosome entry site
An internal ribosome entry site, abbreviated IRES, is a nucleotide sequence that allows for translation initiation in the middle of a messenger RNA sequence as part of the greater process of protein synthesis...
(IRES) of the pestivirus
Pestivirus
Pestivirus is a genus of viruses that belong to the family Flaviviridae. Viruses in the genus Pestivirus infect mammals, including members of the family Bovidae and the family Suidae .-Virus Genetics and Structure:Pestivirus viruses have a single strand of...
es. The pestivirus IRES allows cap and end-independent translation of mRNA in the host cell. The IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre-initiation complex directly to the initiation codon and eliminates the requirement for the eukaryotic initiation factor
Eukaryotic initiation factor
Eukaryotic initiation factors are proteins involved in the initiation phase of eukaryotic translation. They function in forming a complex with the 40S ribosomal subunit and Met-tRNAi called the 43S preinitation complex , recognizing the 5' cap structure of mRNA and recruiting the 43S PIC to mRNA,...
, eIF4F. The classical swine fever virus UTR describedappears to be longer at the 5' end than other pestivirus UTRs. This family represents the conserved core.