Panadiplon
Encyclopedia
Panadiplon is an anxiolytic
drug with a novel chemical structure
that is not closely related to other drugs of this type. It has a similar pharmacological profile to the benzodiazepine
family of drugs, but with mainly anxiolytic properties and relatively little sedative
or amnestic effect, and so is classified as a nonbenzodiazepine
anxiolytic.
Panadiplon acts as a high-affinity GABAA receptor partial agonist
, but despite showing a useful effects profile of a potent anxiolytic with little sedative effects, panadiplon was discontinued from clinical development for use in humans after showing evidence of liver damage in both animals and human trials. Panadiplon however continues to be used in animal research, mainly as a subtype-selective reference drug to compare other GABAA agonists against.
Anxiolytic
An anxiolytic is a drug used for the treatment of anxiety, and its related psychological and physical symptoms...
drug with a novel chemical structure
Chemical structure
A chemical structure includes molecular geometry, electronic structure and crystal structure of molecules. Molecular geometry refers to the spatial arrangement of atoms in a molecule and the chemical bonds that hold the atoms together. Molecular geometry can range from the very simple, such as...
that is not closely related to other drugs of this type. It has a similar pharmacological profile to the benzodiazepine
Benzodiazepine
A benzodiazepine is a psychoactive drug whose core chemical structure is the fusion of a benzene ring and a diazepine ring...
family of drugs, but with mainly anxiolytic properties and relatively little sedative
Sedative
A sedative or tranquilizer is a substance that induces sedation by reducing irritability or excitement....
or amnestic effect, and so is classified as a nonbenzodiazepine
Nonbenzodiazepine
The nonbenzodiazepines, also called benzodiazepine-like drugs, are a class of psychoactive drugs pharmacologically resembling the benzodiazepines, with similar benefits, side effects and risks, despite having dissimilar or entirely different chemical structures.-Classes:There are currently three...
anxiolytic.
Panadiplon acts as a high-affinity GABAA receptor partial agonist
Partial agonist
Partial agonists bind and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist...
, but despite showing a useful effects profile of a potent anxiolytic with little sedative effects, panadiplon was discontinued from clinical development for use in humans after showing evidence of liver damage in both animals and human trials. Panadiplon however continues to be used in animal research, mainly as a subtype-selective reference drug to compare other GABAA agonists against.