PALM
Encyclopedia
Paralemmin is a protein
that in humans is encoded by the PALM gene
.
This gene encodes a member of the paralemmin protein
family. Other members of this family include CAP-23
, GAP-43
, MARCKS
, and MacMARCKS
. The product of this gene is a prenylated
and palmitoylated
phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the PALM gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
This gene encodes a member of the paralemmin protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
family. Other members of this family include CAP-23
BASP1
Brain acid soluble protein 1 is a protein that in humans is encoded by the BASP1 gene.-Further reading:...
, GAP-43
Gap-43 protein
Growth Associated Protein 43 also known as Gap43 is a protein that in humans is encoded by the GAP43 gene.Gap43 has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development, during axonal regeneration and is phosphorylated...
, MARCKS
MARCKS
Myristoylated alanine-rich C-kinase substrate is an enzyme that in humans is encoded by the MARCKS gene.-Further reading:...
, and MacMARCKS
MARCKSL1
MARCKS-related protein is a protein that in humans is encoded by the MARCKSL1 gene.-Further reading:...
. The product of this gene is a prenylated
Prenylation
Prenylation, or isoprenylation, or lipidation is the addition of hydrophobic molecules to a protein. It is usually assumed that prenyl groups facilitate attachment to cell membranes, similar to lipid anchor like the GPI anchor, though direct evidence is missing...
and palmitoylated
Palmitoylation
S-Palmitoylation is the covalent attachment of fatty acids, such as palmitic acid, to cysteine residues of membrane proteins. The precise function of palmitoylation depends on the particular protein being considered. Palmitoylation enhances the hydrophobicity of proteins and contributes to their...
phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.