Osteoglycin encoded by the OGN gene is a human protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

.

This gene encodes a protein which induces ectopic bone formation in conjunction with transforming growth factor

Transforming growth factor

Transforming growth factor is used to describe two classes of polypeptide growth factors, TGFα and TGFβ....

 beta. This protein is a small proteoglycan which contains tandem leucine

Leucine

Leucine is a branched-chain α-amino acid with the chemical formula HO2CCHCH2CH2. Leucine is classified as a hydrophobic amino acid due to its aliphatic isobutyl side chain. It is encoded by six codons and is a major component of the subunits in ferritin, astacin and other 'buffer' proteins...

-rich repeats (LRR). The gene expresses three transcript

Alternative splicing

Alternative splicing is a process by which the exons of the RNA produced by transcription of a gene are reconnected in multiple ways during RNA splicing...

 variants.

The level of expression of this gene has been correlated with enlarged hearts and more specifically left ventricular hypertrophy

Left ventricular hypertrophy

Left ventricular hypertrophy is the thickening of the myocardium of the left ventricle of the heart.-Causes:While ventricular hypertrophy occurs naturally as a reaction to aerobic exercise and strength training, it is most frequently referred to as a pathological reaction to cardiovascular...

.

Further reading