Neutersol is a brand name for Zinc Gluconate (neutralized by Arginine), a compound used to produce infertility in the male dog by chemical disruption of the testicle, intended as an alternative to surgical neutering

Neutering

Neutering, from the Latin neuter , is the removal of an animal's reproductive organ, either all of it or a considerably large part. The process is often used in reference to males whereas spaying is often reserved for females. Colloquially, both terms are often referred to as fixing...

. Neutersol was developed by Pet Healthcare International, Inc.  Neutersol was approved by the U.S. Food and Drug Administration (FDA) for small puppies in 2003. In 2005 however, Pet Healthcare International severed its ties with its manufacturing partner Addison Biologicals, and production of the drug stopped. Neutersol had been expected to be reintroduced into the market by early 2009, but that plan was stalled. Ark Sciences, Inc. now has acquired the intellectual property to this method of sterilization and plans to reintroduce to the US market in 2012 using the safer Esterilsol injection technique used internationally.

Neutersol is contraindicated in cases of cryptorchidism

Cryptorchidism

Cryptorchidism is the absence of one or both testes from the scrotum. It is the most common birth defect regarding male genitalia. In unique cases, cryptorchidism can develop later in life, often as late as young adulthood. About 3% of full-term and 30% of premature infant boys are born with at...

, pre-existing scrotal dermatitis, testicular diseases and malformations, and drug hypersensitivity on Neutersol components.