Neoflavonoid
Encyclopedia
Neoflavonoids are a class of polyphenolic compounds. While flavonoid
Flavonoid
Flavonoids , are a class of plant secondary metabolites....

s (in the narrow sense) have the 2-phenylchromen-4-one backbone, neoflavonoids have the 4-phenylchromen backbone with no hydroxyl group substitution at position 2.

Types

Neoflavonoids include 4-arylcoumarins (neoflavones), 4-arylchromanes, dalbergiones and dalbergiquinols.
  • Neoflavones are derived from the 4-phenylcoumarin (or 4-Aryl-coumarin
    Coumarin
    Coumarin is a fragrant chemical compound in the benzopyrone chemical class, found in many plants, notably in high concentration in the tonka bean , vanilla grass , sweet woodruff , mullein , sweet grass , cassia cinnamon and sweet clover...

    ) backbone (C15H12O2, molar mass : 224.25g/mol, exact mass : 224.083729). The first neoflavone isolated from natural sources in 1951 was calophyllolide from Calophyllum inophyllum
    Calophyllum inophyllum
    Calophyllum inophyllum is a large evergreen. It is native from East Africa, southern coastal India to Malesia and Australia.-Distribution and description:...

    seeds.
  • Neoflavenes possess the 4-phenylchromen backbone (chemical formula : C15H10O2, exact mass : 222.0680792). Dalbergichromene
    Dalbergichromene
    Dalbergichromene is a neoflavene, a type of neoflavonoids which are themselves a type of polyphenolic compounds. Dalbergichromene can be extracted from the stem-bark and heartwood of Dalbergia sissoo...

    , extracted from the stem-bark and heartwood of Dalbergia sissoo
    Dalbergia sissoo
    Dalbergia sissoo, known as Shisham, is an erect deciduous tree, native to the Indian Subcontinent. It is also called sissoo, sisu, sheesham, tahli and sometimes referred to as Indian Rosewood. It is state tree of Punjab state and provincial tree of Punjab province...

    , is an example of such compounds

Other examples

  • Coutareagenin (5-hydroxy-7-methoxy-4-(3,4-dihydroxyphenyl)-2H-benzo-1-pyran-2-on) found in Hintonia latiflora
    Hintonia latiflora
    Hintonia latiflora is a plant species in the genus Hintonia.Hintonia latiflora contains the neoflavonoid coutareagenin Hintonia latiflora is a plant species in the genus Hintonia.Hintonia latiflora contains the neoflavonoid coutareagenin Hintonia latiflora is a plant species in the genus...

  • Dalbergin
  • Nivetin isolated from Echinops niveus
    Echinops niveus
    Echinops niveus is a species in the genus Echinops or globe thistles. It is native to the Indian subcontinent: Himachal Pradesh, Jammu and Kashmir, Uttar Pradesh, Nepal.Nivetin is a neoflavonoid isolated from E. niveus....

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