Negative electron-transfer dissociation
Encyclopedia
Negative electron-transfer dissociation (NETD) is an ion/ion reaction in which an electron
from an anionic specie is transferred to cationic reagent. Following this transfer event, the electron deficient anion undergoes internal rearrangement and fragments. NETD is the ion/ion analogue of electron-detachment dissociation (EDD)
.
and proteins along the backbone at the Cα-C bond. The resulting fragments are usually a•- and x-type product ions.
Electron
The electron is a subatomic particle with a negative elementary electric charge. It has no known components or substructure; in other words, it is generally thought to be an elementary particle. An electron has a mass that is approximately 1/1836 that of the proton...
from an anionic specie is transferred to cationic reagent. Following this transfer event, the electron deficient anion undergoes internal rearrangement and fragments. NETD is the ion/ion analogue of electron-detachment dissociation (EDD)
Electron-detachment dissociation
Electron-detachment dissociation is a method for fragmenting anionic species in mass spectrometry....
.
Peptide fragmentation mechanism
NETD is compatible with fragmenting peptidePeptide
Peptides are short polymers of amino acid monomers linked by peptide bonds. They are distinguished from proteins on the basis of size, typically containing less than 50 monomer units. The shortest peptides are dipeptides, consisting of two amino acids joined by a single peptide bond...
and proteins along the backbone at the Cα-C bond. The resulting fragments are usually a•- and x-type product ions.
See also
- Electron-transfer dissociation (ETD)
- Electron-detachment dissociation (EDD)Electron-detachment dissociationElectron-detachment dissociation is a method for fragmenting anionic species in mass spectrometry....
- Electron-capture dissociation (ECD)