NKX-homeodomain factor
Encyclopedia
NKX-homeodomain factors are a family of homeodomain
transcription factor
s that are critical regulators of organ development
.
Human genes that encode NKX-homeodomain factors include:
Homeobox
A homeobox is a DNA sequence found within genes that are involved in the regulation of patterns of anatomical development in animals, fungi and plants.- Discovery :...
transcription factor
Transcription factor
In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...
s that are critical regulators of organ development
Developmental biology
Developmental biology is the study of the process by which organisms grow and develop. Modern developmental biology studies the genetic control of cell growth, differentiation and "morphogenesis", which is the process that gives rise to tissues, organs and anatomy.- Related fields of study...
.
Human genes that encode NKX-homeodomain factors include:
- NKX1-1, NKX1-2
- NKX2-1, NKX2-2NKX2-2Homeobox protein Nkx-2.2 is a protein that in humans is encoded by the NKX2-2 gene.Homeobox protein Nkx-2.2 contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated...
, NKX2-4, NKX2-8 - NKX3-1NKX3-1Homeobox protein Nkx-3.1 is a protein that in humans is encoded by the NKX3-1 gene.- External links :...
, NKX3-2NKX3-2NK3 homeobox 2 also known as NKX3-2 is a human gene. It is a homolog of bagpipe in Drosophila and therefore also known as Bapx1 . The protein encoded by this gene is a homeo domain containing transcription factor.-Function:NKX3-2 plays a role in the development of the skeleton... - NKX6-1NKX6-1Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.- Function :In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target...
, NKX6-2NKX6-2Homeobox protein Nkx-6.2 is a protein that in humans is encoded by the NKX6-2 gene.-Further reading:...
, NKX6-3