NFKB1
Encyclopedia
Nuclear factor NF-kappa-B p105 subunit is a protein
that in humans is encoded by the NFKB1 gene
.
This gene encodes a 105 kD protein
which can undergo cotranslational processing by the 26S proteasome
to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappaB (NF-κB) protein complex. NF-κB is a transcription factor
that is activated by various intra- and extra-cellular stimuli such as cytokine
s, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NF-κB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions; over 200 known genes are targets of NF-κB in various cell types, under specific conditions. Inappropriate activation of NF-κB has been associated with a number of inflammatory diseases while persistent inhibition of NF-κB leads to inappropriate immune cell development or delayed cell growth.
with NFKBIE
, IKK2
, MAP3K7IP2
, STAT6
, ITGB3BP
, IκBα, NFKB2
, RELA
, RELB
, TSC22D3
, NOTCH1
, HDAC1
, LYL1
, BCL3
, STAT3
, MAP3K8
, MEN1
, Nuclear receptor coactivator 1
and HMGA2
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the NFKB1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
This gene encodes a 105 kD protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
which can undergo cotranslational processing by the 26S proteasome
Proteasome
Proteasomes are very large protein complexes inside all eukaryotes and archaea, and in some bacteria. In eukaryotes, they are located in the nucleus and the cytoplasm. The main function of the proteasome is to degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks...
to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappaB (NF-κB) protein complex. NF-κB is a transcription factor
Transcription factor
In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...
that is activated by various intra- and extra-cellular stimuli such as cytokine
Cytokine
Cytokines are small cell-signaling protein molecules that are secreted by the glial cells of the nervous system and by numerous cells of the immune system and are a category of signaling molecules used extensively in intercellular communication...
s, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NF-κB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions; over 200 known genes are targets of NF-κB in various cell types, under specific conditions. Inappropriate activation of NF-κB has been associated with a number of inflammatory diseases while persistent inhibition of NF-κB leads to inappropriate immune cell development or delayed cell growth.
Interactions
NFKB1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with NFKBIE
NFKBIE
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon, also known as NFKBIE, is a protein which in humans is encoded by the NFKBIE gene.- Function :...
, IKK2
IKK2
IKK-β also known as inhibitor of nuclear factor kappa-B kinase subunit beta is a protein that in humans is encoded by the IKBKB gene.- Function :...
, MAP3K7IP2
MAP3K7IP2
Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 is an enzyme that in humans is encoded by the MAP3K7IP2 gene.The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK...
, STAT6
STAT6
STAT6 is a human gene. The protein encoded by this gene is a member of the STAT family of transcription factors.In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell...
, ITGB3BP
ITGB3BP
Centromere protein R is a protein that in humans is encoded by the ITGB3BP gene.-Interactions:ITGB3BP has been shown to interact with Retinoid X receptor gamma, Cyclin A2, NFKB1, Retinoid X receptor alpha, Thyroid hormone receptor alpha and CD61....
, IκBα, NFKB2
NFKB2
Nuclear factor NF-kappa-B p100 subunit is a protein that in humans is encoded by the NFKB2 gene.-Interactions:NFKB2 has been shown to interact with NFKBIE, BCL3, MAP3K8, BTRC, RELA, RELB, NFKB1, REL and TSC22D3.-Further reading:...
, RELA
RELA
Transcription factor p65 is a protein that in humans is encoded by the RELA gene.-Interactions:RELA has been shown to interact with NFKBIB, ETHE1, NFKBIE, RFC1, TRIB3, CREB binding protein, Neutrophil cytosolic factor 1, Glucocorticoid receptor, MTPN, BRCA1, C-Fos, POU2F1, BTRC, TATA-binding...
, RELB
RELB
Transcription factor RelB is a protein that in humans is encoded by the RELB gene.-Interactions:RELB has been shown to interact with NFKB2 and NFKB1.-References:...
, TSC22D3
TSC22D3
TSC22 domain family protein 3 is a protein that in humans is encoded by the TSC22D3 gene.-Interactions:TSC22D3 has been shown to interact with C-Raf, NFKB2 and NFKB1.-Further reading:...
, NOTCH1
NOTCH1
Notch homolog 1, translocation-associated , also known as NOTCH1, is a human gene encoding a single-pass transmembrane receptor.A deficiency can be associated with bicuspid aortic valve....
, HDAC1
HDAC1
Histone deacetylase 1 is an enzyme that in humans is encoded by the HDAC1 gene.-Interactions:HDAC1 has been shown to interact with RAD9A, DNMT3L, MTA1, FKBP3, CDC20, CDH1, Host cell factor C1, BUB3, Nuclear receptor co-repressor 2, IKZF1, Prohibitin, EVI1, DDX5, DNMT3A, Mothers against...
, LYL1
LYL1
Protein lyl-1 is a protein that in humans is encoded by the LYL1 gene.-Interactions:LYL1 has been shown to interact with TCF3 and NFKB1....
, BCL3
BCL3
B-cell lymphoma 3-encoded protein is a protein that in humans is encoded by the BCL3 gene.This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin...
, STAT3
STAT3
Signal transducer and activator of transcription 3 also known as STAT3 is a transcription factor which in humans is encoded by the STAT3 gene.- Function :The protein encoded by this gene is a member of the STAT protein family...
, MAP3K8
MAP3K8
Mitogen-activated protein kinase 8 is an enzyme that in humans is encoded by the MAP3K8 gene.-Interactions:MAP3K8 has been shown to interact with AKT1, CHUK, NFKB2 and NFKB1.-Further reading:...
, MEN1
MEN1
Menin is a protein that in humans is encoded by the MEN1 gene. Menin is a putative tumor suppressor associated with multiple endocrine neoplasia type 1....
, Nuclear receptor coactivator 1
Nuclear receptor coactivator 1
The nuclear receptor coactivator 1 is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity . NCOA1 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA1, in turn, acylates...
and HMGA2
HMGA2
High-mobility group AT-hook 2, also known as HMGA2, is a protein that, in humans, is encoded by the HMGA2 gene.- Function :This gene encodes a protein that belongs to the non-histone chromosomal high-mobility group protein family. HMG proteins function as architectural factors and are essential...
.