Mycobacterium kubicae
Encyclopedia
Mycobacterium kubicae
, nonmotile and acid-fast
rods. Cells are typically rod-shaped, with some coccoid forms.
Colony characteristics
Physiology
Pathogenicity.
Distribution.
Strain ATCC 700732 = CDC 941078 = CIP 106428 = DSM 44627 = JCM 13573.
Description
Gram-positiveGram-positive
Gram-positive bacteria are those that are stained dark blue or violet by Gram staining. This is in contrast to Gram-negative bacteria, which cannot retain the crystal violet stain, instead taking up the counterstain and appearing red or pink...
, nonmotile and acid-fast
Acid-fast
Acid-fastness is a physical property of certain bacteria, specifically their resistance to decolorization by acids during staining procedures.Acid-fast organisms are difficult to characterize using standard microbiological techniques Acid-fastness is a physical property of certain bacteria,...
rods. Cells are typically rod-shaped, with some coccoid forms.
Colony characteristics
- Smooth and domed, with a yellow scotochromogenicScotochromogenicScotochromogenic bacteria develop pigment in the dark or in the light. Runyon Group II nontuberculous mycobacteria are examples but the term could apply to many other organisms....
pigment on Middlebrook 7H11 agar, film like on Löwenstein-Jensen media.
Physiology
- Mature growth in 21 days between 33°C and 37°C.
- Isolates are resistant to amikacinAmikacinAmikacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Amikacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.-Administration:Amikacin may be...
and rifampin - Partially resistant to ciprofloxacinCiprofloxacinCiprofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class.It is a second-generation fluoroquinolone antibacterial. It kills bacteria by interfering with the enzymes that cause DNA to rewind after being copied, which stops synthesis of DNA and of...
, cycloserineCycloserineCycloserine is an antibiotic effective against Mycobacterium tuberculosis. For the treatment of tuberculosis, it is classified as a second line drug, i.e...
, ethambutolEthambutolEthambutol is a bacteriostatic antimycobacterial drug prescribed to treat tuberculosis. It is usually given in combination with other tuberculosis drugs, such as isoniazid, rifampicin and pyrazinamide....
, isoniazidIsoniazidIsoniazid , also known as isonicotinylhydrazine , is an organic compound that is the first-line antituberculosis medication in prevention and treatment. It was first discovered in 1912, and later in 1951 it was found to be effective against tuberculosis by inhibiting its mycolic acid...
, rifabutinRifabutinRifabutin is a bactericidal antibiotic drug primarily used in the treatment of tuberculosis. The drug is a semi-synthetic derivative of rifamycin S. Its effect is based on blocking the DNA-dependent RNA-polymerase of the bacteria. It is effective against Gram-positive and some Gram-negative...
and streptomycinStreptomycinStreptomycin is an antibiotic drug, the first of a class of drugs called aminoglycosides to be discovered, and was the first antibiotic remedy for tuberculosis. It is derived from the actinobacterium Streptomyces griseus. Streptomycin is a bactericidal antibiotic. Streptomycin cannot be given...
, - Susceptible to clarithromycinClarithromycinClarithromycin is a macrolide antibiotic used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia , skin and skin structure infections...
, clofazimineClofazimineClofazimine is a fat-soluble riminophenazine dye used in combination with rifampicin and dapsone as multidrug therapy for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients and...
and ethionamideEthionamideEthionamide is an antibiotic used in the treatment of tuberculosis.It is a prodrug.It has been proposed for use in combination with gatifloxacin.The action may be through disruption of mycolic acid.-Synthesis:...
.
Pathogenicity.
Distribution.
Type strain
- The type strain was isolated from human sputumSputumSputum is mucus that is coughed up from the lower airways. It is usually used for microbiological investigations of respiratory infections....
.
Strain ATCC 700732 = CDC 941078 = CIP 106428 = DSM 44627 = JCM 13573.