Mitozolomide
Encyclopedia
Mitozolomide is an antineoplastic. It is an imidazotetrazine derivative.
Development of mitozolomide was discontinued during Phase II clinical trial
s after it was found to cause severe and unpredictable bone marrow suppression. Temozolomide
, which has been in clinical use since 1999, is a less toxic analogue
of mitozolomide.
Development of mitozolomide was discontinued during Phase II clinical trial
Clinical trial
Clinical trials are a set of procedures in medical research and drug development that are conducted to allow safety and efficacy data to be collected for health interventions...
s after it was found to cause severe and unpredictable bone marrow suppression. Temozolomide
Temozolomide
Temozolomide Temozolomide Temozolomide (brand names Temodar and Temodal is an oral alkylating agent which can be used for the treatment of Grade IV astrocytoma — an aggressive brain tumor, also known as glioblastoma multiforme as well as melanoma, a form of skin cancer...
, which has been in clinical use since 1999, is a less toxic analogue
Analog (chemistry)
In chemistry, a structural analog , also known as chemical analog or simply analog, is a compound having a structure similar to that of another one, but differing from it in respect of a certain component. It can differ in one or more atoms, functional groups, or substructures, which are replaced...
of mitozolomide.