Mir-17 microRNA precursor family
Encyclopedia
The miR-17 microRNA precursor family are a group of related small non-coding RNA
genes called microRNAs that regulate gene expression
. The microRNA precursor miR-17 family, includes miR-20, miR-91, and miR-103
. miRNAs are transcribed as ~70 nucleotide
precursors and subsequently processed by the Dicer
enzyme to give a ~22 nucleotide
product. In this case the mature sequence comes from the 3' arm of the precursor. The products are thought to have regulatory roles through complementarity to the 3' UTR of mRNA.
A screen of 17 miRNAs that have been predicted to regulate a number of breast cancer associated genes found variations in the microRNAs
miR-17 and miR-30c-1
, these patients were noncarriers of BRCA1
or BRCA2
mutations, lending the possibility that familial breast cancer may be caused by variation in these miRNAs.
Non-coding RNA
A non-coding RNA is a functional RNA molecule that is not translated into a protein. Less-frequently used synonyms are non-protein-coding RNA , non-messenger RNA and functional RNA . The term small RNA is often used for short bacterial ncRNAs...
genes called microRNAs that regulate gene expression
Gene expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product. These products are often proteins, but in non-protein coding genes such as ribosomal RNA , transfer RNA or small nuclear RNA genes, the product is a functional RNA...
. The microRNA precursor miR-17 family, includes miR-20, miR-91, and miR-103
Mir-103/107 microRNA precursor
The miR-103 microRNA precursor , is a short non-coding RNA gene involved in gene regulation.miR-103 and miR-107 have now been predicted or experimentally confirmed in human....
. miRNAs are transcribed as ~70 nucleotide
Nucleotide
Nucleotides are molecules that, when joined together, make up the structural units of RNA and DNA. In addition, nucleotides participate in cellular signaling , and are incorporated into important cofactors of enzymatic reactions...
precursors and subsequently processed by the Dicer
Dicer
Dicer is an endoribonuclease in the RNase III family that cleaves double-stranded RNA and pre-microRNA into short double-stranded RNA fragments called small interfering RNA about 20-25 nucleotides long, usually with a two-base overhang on the 3' end...
enzyme to give a ~22 nucleotide
Nucleotide
Nucleotides are molecules that, when joined together, make up the structural units of RNA and DNA. In addition, nucleotides participate in cellular signaling , and are incorporated into important cofactors of enzymatic reactions...
product. In this case the mature sequence comes from the 3' arm of the precursor. The products are thought to have regulatory roles through complementarity to the 3' UTR of mRNA.
A screen of 17 miRNAs that have been predicted to regulate a number of breast cancer associated genes found variations in the microRNAs
miR-17 and miR-30c-1
Mir-30 microRNA precursor
miR-30 microRNA precursor is a small non-coding RNA that regulates gene expression. Animal microRNAs are transcribed as ~70 nucleotide stem-loop precursor and subsequently processed by the Dicer enzyme to give a mature ~22 nucleotide product. In this case the mature sequence comes from both the 3' ...
, these patients were noncarriers of BRCA1
BRCA1
BRCA1 is a human caretaker gene that produces a protein called breast cancer type 1 susceptibility protein, responsible for repairing DNA. The first evidence for the existence of the gene was provided by the King laboratory at UC Berkeley in 1990...
or BRCA2
BRCA2
BRCA2 is a protein that in humans is encoded by the BRCA2 gene.BRCA2 orthologs have been identified in most mammals for which complete genome data are available....
mutations, lending the possibility that familial breast cancer may be caused by variation in these miRNAs.